ID   VAB2_VANPO              Reviewed;         352 AA.
AC   A7TP22;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit VAB2;
DE            Short=BLOC-1 subunit VAB2;
GN   Name=VAB2; ORFNames=Kpol_499p19;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) involved in endosomal cargo sorting. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1
CC       and VAB2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}. Vacuole
CC       {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VAB2 family. {ECO:0000305}.
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DR   EMBL; DS480437; EDO15991.1; -; Genomic_DNA.
DR   RefSeq; XP_001643849.1; XM_001643799.1.
DR   AlphaFoldDB; A7TP22; -.
DR   SMR; A7TP22; -.
DR   STRING; 436907.A7TP22; -.
DR   EnsemblFungi; EDO15991; EDO15991; Kpol_499p19.
DR   GeneID; 5544099; -.
DR   KEGG; vpo:Kpol_499p19; -.
DR   eggNOG; ENOG502S95F; Eukaryota.
DR   HOGENOM; CLU_788007_0_0_1; -.
DR   InParanoid; A7TP22; -.
DR   OrthoDB; 1601198at2759; -.
DR   PhylomeDB; A7TP22; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005773; C:vacuole; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoplasmic vesicle; Reference proteome; Transport;
KW   Vacuole.
FT   CHAIN           1..352
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit VAB2"
FT                   /id="PRO_0000320514"
FT   REGION          299..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          57..133
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   352 AA;  40102 MW;  7101F9DD3860A065 CRC64;
     MRNKLNFQNI EHSYAFKELS KLPSIVSSKQ LRTNSIFEAV KPELKNVQND IQMFYSVIER
     EINSEISQID LVETELKKSL KNVNKSYAKI MKRRTILSSN GKNKNLAIVD DFNKEVDGLE
     SLITGLKETV HDMIDDLVTA DSQLKSNNKS VTKEEINSQH YPLLFEILQK DYNHIFKESN
     NLSVQDADRK SIELDIEDRT EVKSSDDKDS MNKNINIMPI EDNSITHLSF EGEPIYTKVS
     HENSNQVTDK GINQLDENTL NQEIKNDNLI CQRSLPPKNL SNENVVNDNY ADSNCLKEEK
     KNEVDTSKSK MGTINSTPSS TTMGNGFILP NLTKVVKPTI STTFETVVNR EF