ID   VAB7_CAEEL              Reviewed;         247 AA.
AC   Q93899; Q23093;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Homeobox protein vab-7;
GN   Name=vab-7; ORFNames=M142.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND MUTAGENESIS OF ARG-119.
RC   STRAIN=Bristol N2; TISSUE=Embryo;
RX   PubMed=8654927; DOI=10.1101/gad.10.9.1120;
RA   Ahringer J.;
RT   "Posterior patterning by the Caenorhabditis elegans even-skipped homolog
RT   vab-7.";
RL   Genes Dev. 10:1120-1130(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=28056346; DOI=10.1016/j.neuron.2016.11.036;
RA   Kerk S.Y., Kratsios P., Hart M., Mourao R., Hobert O.;
RT   "Diversification of C. elegans Motor Neuron Identity via Selective Effector
RT   Gene Repression.";
RL   Neuron 93:80-98(2017).
CC   -!- FUNCTION: Transcription factor (PubMed:28056346). Involved in motor
CC       neuron fate determination and maintenance, acting as a transcriptional
CC       repressor to counteract gene activation by transcription factor unc-3
CC       in a subset of motor neurons (PubMed:28056346). Probably acts by
CC       binding to specific promoter elements (PubMed:28056346). Required for
CC       posterior-specific pattern formation in the embryo and may have a role
CC       in regulating egl-5 expression (PubMed:8654927).
CC       {ECO:0000269|PubMed:28056346, ECO:0000269|PubMed:8654927}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Embryo, L1 and L2 larvae.
CC       {ECO:0000269|PubMed:8654927}.
CC   -!- SIMILARITY: Belongs to the even-skipped homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA65441.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X96636; CAA65441.1; ALT_INIT; mRNA.
DR   EMBL; Z73428; CAA97809.1; -; Genomic_DNA.
DR   PIR; T23763; T23763.
DR   PIR; T43629; T43629.
DR   RefSeq; NP_499401.1; NM_067000.4.
DR   AlphaFoldDB; Q93899; -.
DR   SMR; Q93899; -.
DR   BioGRID; 41708; 12.
DR   IntAct; Q93899; 9.
DR   STRING; 6239.M142.4; -.
DR   PaxDb; Q93899; -.
DR   EnsemblMetazoa; M142.4.1; M142.4.1; WBGene00006873.
DR   GeneID; 176521; -.
DR   KEGG; cel:CELE_M142.4; -.
DR   UCSC; M142.4; c. elegans.
DR   CTD; 176521; -.
DR   WormBase; M142.4; CE12432; WBGene00006873; vab-7.
DR   eggNOG; KOG0844; Eukaryota.
DR   GeneTree; ENSGT00940000168391; -.
DR   HOGENOM; CLU_1103598_0_0_1; -.
DR   InParanoid; Q93899; -.
DR   OMA; YDNRDDG; -.
DR   OrthoDB; 1540011at2759; -.
DR   SignaLink; Q93899; -.
DR   PRO; PR:Q93899; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00006873; Expressed in embryonic cell and 9 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..247
FT                   /note="Homeobox protein vab-7"
FT                   /id="PRO_0000049349"
FT   DNA_BIND        68..127
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          194..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         119
FT                   /note="R->C: In ED7; partial loss of function."
FT                   /evidence="ECO:0000269|PubMed:8654927"
SQ   SEQUENCE   247 AA;  26819 MW;  8387AA3FEABB8BE7 CRC64;
     MQSFDIESLI GVNKVPSLVE MVAASRASSF SPPFEQQHHD PMGVVAAAAA AAAAGRHHPY
     DNRDDGQMRR YRTAFSREQI GRLEREFAKE NYVSRKTRGE LAAELNLPEG TIKVWFQNRR
     MKDKRQRVGG LAWPFPPQMA AYMLNPFAYE MWMKTAAASQ FGATGPGNGA YGNNGSSTSP
     SAAGSLPFLP PLGFPSFLSQ NSTKSPSSPH SDDSSKSKNT SSDDDESKPV NFSNSPSSSS
     PSPYSTD