VAB_ARATH
ID VAB_ARATH Reviewed; 498 AA.
AC Q8W4K5; Q9M1W0;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=VAN3-binding protein {ECO:0000303|PubMed:19363154};
DE AltName: Full=Protein FORKED 1;
GN Name=VAB {ECO:0000303|PubMed:19363154}; Synonyms=FKD1;
GN OrderedLocusNames=At3g63300 {ECO:0000312|Araport:AT3G63300};
GN ORFNames=F16M2_150 {ECO:0000312|EMBL:CAB86431.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP INTERACTION WITH VAN3.
RX PubMed=19363154; DOI=10.1242/dev.030098;
RA Naramoto S., Sawa S., Koizumi K., Uemura T., Ueda T., Friml J., Nakano A.,
RA Fukuda H.;
RT "Phosphoinositide-dependent regulation of VAN3 ARF-GAP localization and
RT activity essential for vascular tissue continuity in plants.";
RL Development 136:1529-1538(2009).
CC -!- SUBUNIT: Interacts with VAN3. {ECO:0000269|PubMed:19363154}.
CC -!- INTERACTION:
CC Q8W4K5; Q5W7F2: AGD3; NbExp=5; IntAct=EBI-10769249, EBI-994222;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q8W4K5-1; Sequence=Displayed;
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB86431.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL138648; CAB86431.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE80464.1; -; Genomic_DNA.
DR EMBL; AY062506; AAL32584.1; -; mRNA.
DR EMBL; BT002092; AAN72103.1; -; mRNA.
DR PIR; T48119; T48119.
DR RefSeq; NP_191889.2; NM_116195.3. [Q8W4K5-1]
DR AlphaFoldDB; Q8W4K5; -.
DR IntAct; Q8W4K5; 1.
DR STRING; 3702.AT3G63300.1; -.
DR PaxDb; Q8W4K5; -.
DR ProteomicsDB; 228546; -. [Q8W4K5-1]
DR EnsemblPlants; AT3G63300.1; AT3G63300.1; AT3G63300. [Q8W4K5-1]
DR GeneID; 825505; -.
DR Gramene; AT3G63300.1; AT3G63300.1; AT3G63300. [Q8W4K5-1]
DR KEGG; ath:AT3G63300; -.
DR Araport; AT3G63300; -.
DR TAIR; locus:2077294; AT3G63300.
DR eggNOG; ENOG502QRT3; Eukaryota.
DR HOGENOM; CLU_033023_0_0_1; -.
DR InParanoid; Q8W4K5; -.
DR OrthoDB; 891791at2759; -.
DR PhylomeDB; Q8W4K5; -.
DR PRO; PR:Q8W4K5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8W4K5; baseline and differential.
DR Genevisible; Q8W4K5; AT.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IMP:TAIR.
DR GO; GO:0010305; P:leaf vascular tissue pattern formation; IMP:TAIR.
DR GO; GO:0010087; P:phloem or xylem histogenesis; IMP:TAIR.
DR GO; GO:0006892; P:post-Golgi vesicle-mediated transport; IDA:TAIR.
DR GO; GO:0009733; P:response to auxin; IEP:TAIR.
DR InterPro; IPR008546; DUF828.
DR InterPro; IPR013666; PH_pln.
DR InterPro; IPR040269; VAB.
DR PANTHER; PTHR31351; PTHR31351; 1.
DR Pfam; PF05703; Auxin_canalis; 1.
DR Pfam; PF08458; PH_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..498
FT /note="VAN3-binding protein"
FT /id="PRO_0000433261"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 498 AA; 53335 MW; 633026046AB486B3 CRC64;
MERELRRPNP INSSRRPEIF SSGGSSTQLP ESPRGPMEFL SRSWSVSALE VSRALHTAKS
ASATNRPPSS INTPIPEETL NPEKEECPPE NSTSVSSQFS FAASATSQLV LERIMSQSEV
SPLTSGRLSH SSGPLNGGGS FTETDSPPIS PSDEFDDVIK YFRTHNTIHP LFSGTGGSRG
TTGNGSNTPM AGTGPKTVGR WLKDRKEKKK EETRTQNAQV HAAVSVAAVA SAVAAVAAAT
AASSPGKNEQ MARIDMAMAS AAALVAAQCV EAAEIMGADR DHLTSVVSSA VNVKSHDDIV
TLTAAAATAL RGAATLKARA LKEVWNIAAV LPAEKGASSA LCGQVDTKHS DSSFSGELPV
AGEDFLGVCN QELLAKGTEL LKRTRGGELH WKIVSVYINK AGQAVLKMKS KHVGGTFTKK
KKHMVLEVRK DIPAWAGRDL FNGDKHHYFG LKTETKRVIE FECRNQREYE IWTQGVSRLL
AIAAEKKQKS SMSKWMAP
