VAC7_SCHPO
ID VAC7_SCHPO Reviewed; 251 AA.
AC O94262;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Vacuolar segregation protein 7;
GN Name=vac7; ORFNames=SPBP8B7.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Component of the PI(3,5)P2 regulatory complex that regulates
CC both the synthesis and turnover of phosphatidylinositol 3,5-
CC bisphosphate (PtdIns(3,5)P2). Directly involved in vacuolar membrane
CC scission. Required for normal vacuole acidification, inheritance and
CC morphology (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the PI(3,5)P2 regulatory complex.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:16823372}; Single-pass type II membrane protein
CC {ECO:0000269|PubMed:16823372}. Golgi apparatus membrane
CC {ECO:0000269|PubMed:16823372}; Single-pass type II membrane protein
CC {ECO:0000269|PubMed:16823372}. Vacuole membrane {ECO:0000250}; Single-
CC pass type II membrane protein {ECO:0000250}.
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DR EMBL; CU329671; CAA21798.1; -; Genomic_DNA.
DR PIR; T40807; T40807.
DR RefSeq; NP_596520.1; NM_001022441.2.
DR AlphaFoldDB; O94262; -.
DR SMR; O94262; -.
DR BioGRID; 277878; 21.
DR STRING; 4896.SPBP8B7.13.1; -.
DR iPTMnet; O94262; -.
DR PaxDb; O94262; -.
DR PRIDE; O94262; -.
DR EnsemblFungi; SPBP8B7.13.1; SPBP8B7.13.1:pep; SPBP8B7.13.
DR GeneID; 2541367; -.
DR KEGG; spo:SPBP8B7.13; -.
DR PomBase; SPBP8B7.13; vac7.
DR VEuPathDB; FungiDB:SPBP8B7.13; -.
DR HOGENOM; CLU_1107661_0_0_1; -.
DR OMA; ESENFVY; -.
DR PRO; PR:O94262; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0071627; C:integral component of fungal-type vacuolar membrane; IC:PomBase.
DR GO; GO:0070772; C:PAS complex; ISO:PomBase.
DR GO; GO:0006644; P:phospholipid metabolic process; ISO:PomBase.
DR InterPro; IPR024260; Vac7.
DR Pfam; PF12751; Vac7; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Membrane;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix;
KW Vacuole.
FT CHAIN 1..251
FT /note="Vacuolar segregation protein 7"
FT /id="PRO_0000351433"
FT TRANSMEM 227..247
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT REGION 154..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 251 AA; 27747 MW; C631E344FDC0D686 CRC64;
MSEPKPMQMS VETETVLNVS QVQIPSSCDR KASLETLKTK KNAQKKKKIS LPNVMTSKAA
MFAARVASAV DQDPNDEESE NFVYENLIPT NDDELHSPSA SIHSFQTYNL PLEMLPTINH
VPYYGSAGTN ALNGGPLSNS RKLIPKRSAK FSSMVGSSDT RCNSPTTARG LATSPLQINP
TTSKSPLLNK KLSSTSQEPF RTSRRSGQES GDVTTKMLRN LLHKRLWISF FFACFVVLSL
VYFHYAVQPL L
