VAC8_ASPFU
ID VAC8_ASPFU Reviewed; 578 AA.
AC Q4WVW4;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Vacuolar protein 8;
GN Name=vac8; ORFNames=AFUA_5G13540;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Functions in both vacuole inheritance and protein targeting
CC from the cytoplasm to vacuole. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Lipid-anchor
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR EMBL; AAHF01000003; EAL91262.1; -; Genomic_DNA.
DR RefSeq; XP_753300.1; XM_748207.1.
DR AlphaFoldDB; Q4WVW4; -.
DR SMR; Q4WVW4; -.
DR STRING; 746128.CADAFUBP00005983; -.
DR SwissPalm; Q4WVW4; -.
DR EnsemblFungi; EAL91262; EAL91262; AFUA_5G13540.
DR GeneID; 3511463; -.
DR KEGG; afm:AFUA_5G13540; -.
DR VEuPathDB; FungiDB:Afu5g13540; -.
DR eggNOG; KOG4224; Eukaryota.
DR HOGENOM; CLU_021483_0_0_1; -.
DR InParanoid; Q4WVW4; -.
DR OMA; VWDKPDG; -.
DR OrthoDB; 688964at2759; -.
DR Proteomes; UP000002530; Chromosome 5.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:EnsemblFungi.
DR GO; GO:0045121; C:membrane raft; IEA:EnsemblFungi.
DR GO; GO:0071563; C:Myo2p-Vac17p-Vac8p transport complex; IEA:EnsemblFungi.
DR GO; GO:0071561; C:nucleus-vacuole junction; IEA:EnsemblFungi.
DR GO; GO:0000407; C:phagophore assembly site; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IEA:EnsemblFungi.
DR GO; GO:0071562; P:nucleus-vacuole junction assembly; IBA:GO_Central.
DR GO; GO:0000425; P:pexophagy; IEA:EnsemblFungi.
DR GO; GO:1903044; P:protein localization to membrane raft; IEA:EnsemblFungi.
DR GO; GO:0034517; P:ribophagy; IEA:EnsemblFungi.
DR GO; GO:0042144; P:vacuole fusion, non-autophagic; IEA:EnsemblFungi.
DR GO; GO:0000011; P:vacuole inheritance; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR045156; Vac8.
DR PANTHER; PTHR47249; PTHR47249; 1.
DR Pfam; PF00514; Arm; 8.
DR SMART; SM00185; ARM; 9.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 7.
PE 3: Inferred from homology;
KW Lipoprotein; Membrane; Reference proteome; Repeat; Vacuole.
FT CHAIN 1..578
FT /note="Vacuolar protein 8"
FT /id="PRO_0000256206"
FT REPEAT 58..95
FT /note="ARM 1"
FT REPEAT 96..135
FT /note="ARM 2"
FT REPEAT 137..176
FT /note="ARM 3"
FT REPEAT 178..217
FT /note="ARM 4"
FT REPEAT 219..258
FT /note="ARM 5"
FT REPEAT 262..301
FT /note="ARM 6"
FT REPEAT 303..342
FT /note="ARM 7"
FT REPEAT 344..384
FT /note="ARM 8"
FT REPEAT 428..467
FT /note="ARM 9"
SQ SEQUENCE 578 AA; 62605 MW; 1ADA92D4857F6298 CRC64;
MTAIANACLS CLSAVDRWCH ITACLGPIGG RSRDGIYETT LADNEREAVS DLLGYLENRA
ETDFFSGEPL RALSTLVYSD NVDLQRSASL TFAEITERDV REVDRDTLEP ILFLLQSSDI
EVQRAASAAL GNLAVNAENK VLIVALGGLT PLIRQMMSPN VEVQCNAVGC ITNLATHEDN
KAKIARSGAL GPLIRLAKSK DMRVQRNATG ALLNMTHSDD NRQQLVNAGA IPVLVQLLSS
PDVDVQYYCT TALSNIAVDA SNRKRLAQTE SRLVQSLVHL MDSSTPKVQC QAALALRNLA
SDEKYQLEIV RAKGLPPLLR LLQSSYLPLI LSAVACIRNI SIHPLNESPI IDAGFLKPLV
DLLGSTDNEE IQCHAISTLR NLAASSDRNK ELVLQAGAVQ KCKDLVLRVP LSVQSEMTAA
IAVLALSDEL KPHLLNLGVF DVLIPLTNSE SIEVQGNSAA ALGNLSSKVG DYSIFVRDWA
DPNGGIHGYL KRFLASGDPT FQHIAIWTLL QLLESEDKRL IGYISKSDDI VQMVKTISDK
NIESDEEDGE DGEAEVIALA RRCLGLLGNG PKQTLVEG
