ID   VAC8_ASPOR              Reviewed;         578 AA.
AC   Q2U5T5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Vacuolar protein 8;
GN   Name=vac8; ORFNames=AO090113000014;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Functions in both vacuole inheritance and protein targeting
CC       from the cytoplasm to vacuole. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR   EMBL; AP007166; BAE63080.1; -; Genomic_DNA.
DR   RefSeq; XP_001824213.1; XM_001824161.2.
DR   AlphaFoldDB; Q2U5T5; -.
DR   SMR; Q2U5T5; -.
DR   STRING; 510516.Q2U5T5; -.
DR   EnsemblFungi; BAE63080; BAE63080; AO090113000014.
DR   GeneID; 5995860; -.
DR   KEGG; aor:AO090113000014; -.
DR   VEuPathDB; FungiDB:AO090113000014; -.
DR   HOGENOM; CLU_021483_0_0_1; -.
DR   OMA; VWDKPDG; -.
DR   Proteomes; UP000006564; Chromosome 5.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:EnsemblFungi.
DR   GO; GO:0045121; C:membrane raft; IEA:EnsemblFungi.
DR   GO; GO:0071563; C:Myo2p-Vac17p-Vac8p transport complex; IEA:EnsemblFungi.
DR   GO; GO:0071561; C:nucleus-vacuole junction; IEA:EnsemblFungi.
DR   GO; GO:0000407; C:phagophore assembly site; IEA:EnsemblFungi.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0043495; F:protein-membrane adaptor activity; IEA:EnsemblFungi.
DR   GO; GO:0000045; P:autophagosome assembly; IEA:EnsemblFungi.
DR   GO; GO:0071562; P:nucleus-vacuole junction assembly; IEA:EnsemblFungi.
DR   GO; GO:0000425; P:pexophagy; IEA:EnsemblFungi.
DR   GO; GO:1903044; P:protein localization to membrane raft; IEA:EnsemblFungi.
DR   GO; GO:0034517; P:ribophagy; IEA:EnsemblFungi.
DR   GO; GO:0042144; P:vacuole fusion, non-autophagic; IEA:EnsemblFungi.
DR   GO; GO:0000011; P:vacuole inheritance; IEA:EnsemblFungi.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR045156; Vac8.
DR   PANTHER; PTHR47249; PTHR47249; 1.
DR   Pfam; PF00514; Arm; 8.
DR   SMART; SM00185; ARM; 9.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 7.
PE   3: Inferred from homology;
KW   Lipoprotein; Membrane; Reference proteome; Repeat; Vacuole.
FT   CHAIN           1..578
FT                   /note="Vacuolar protein 8"
FT                   /id="PRO_0000256207"
FT   REPEAT          58..95
FT                   /note="ARM 1"
FT   REPEAT          96..135
FT                   /note="ARM 2"
FT   REPEAT          137..176
FT                   /note="ARM 3"
FT   REPEAT          178..217
FT                   /note="ARM 4"
FT   REPEAT          219..258
FT                   /note="ARM 5"
FT   REPEAT          262..301
FT                   /note="ARM 6"
FT   REPEAT          303..342
FT                   /note="ARM 7"
FT   REPEAT          344..384
FT                   /note="ARM 8"
FT   REPEAT          428..467
FT                   /note="ARM 9"
SQ   SEQUENCE   578 AA;  62713 MW;  5E96722E1A9C6CB7 CRC64;
     MSGIASACLS CLSTVDRWCH ITACLGPIGG RSRDGIYETT LADNEREAVS DLLGYLENRA
     ETDFFRGEPL SALSTLVYSD NVDLQRSASL TFAEITERDV REVDRDTLEP ILFLLQSSDI
     EVQRAASAAL GNLAVNADNK VLIVALGGLA PLIRQMMSPN VEVQCNAVGC ITNLATHEDN
     KAKIARSGAL GPLIRLAKSK DMRVQRNATG ALLNMTHSDD NRQQLVNAGA IPVLVQLLSS
     SDVDVQYYCT TALSNIAVDA SNRKRLAQTE SRLVQSLVHL MDSSTPKVQC QAALALRNLA
     SDEKYQLEIV RAKGLPPLLR LLQSSYLPLI LSAVACIRNI SIHPLNESPI IDAGFLKPLV
     DLLGSTDNEE IQCHAISTLR NLAASSDRNK ELVLQAGAVQ KCKDLVLKVP LSVQSEMTAA
     IAVLALSDEL KPHLLNLGVF DVLIPLTESE SIEVQGNSAA ALGNLSSKVG DYSIFVRDWA
     DPNGGIHGYL KRFLASGDPT FQHIAIWTLL QLLESEDKRL ISYIAKSDDV VHMVKSISDK
     NIESDEEDQE DGEGEVIALA RRCLEFLGNG PRQTLVEA