VAC8_CANAL
ID VAC8_CANAL Reviewed; 585 AA.
AC Q59MN0; A0A1D8PMA3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Vacuolar protein 8;
GN Name=VAC8; OrderedLocusNames=CAALFM_C405150WA;
GN ORFNames=CaO19.745, CaO19.8364;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=16467476; DOI=10.1128/ec.5.2.359-367.2006;
RA Barelle C.J., Richard M.L., Gaillardin C., Gow N.A.R., Brown A.J.P.;
RT "Candida albicans VAC8 is required for vacuolar inheritance and normal
RT hyphal branching.";
RL Eukaryot. Cell 5:359-367(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Functions in both vacuole inheritance and protein targeting
CC from the cytoplasm to vacuole. Vacuole inheritance has a role in the
CC regulation of hyphal cell division. {ECO:0000269|PubMed:16467476}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Lipid-anchor
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR EMBL; CP017626; AOW29255.1; -; Genomic_DNA.
DR RefSeq; XP_710992.1; XM_705900.1.
DR AlphaFoldDB; Q59MN0; -.
DR SMR; Q59MN0; -.
DR STRING; 237561.Q59MN0; -.
DR PRIDE; Q59MN0; -.
DR GeneID; 3647410; -.
DR KEGG; cal:CAALFM_C405150WA; -.
DR CGD; CAL0000185656; VAC8.
DR VEuPathDB; FungiDB:C4_05150W_A; -.
DR eggNOG; KOG4224; Eukaryota.
DR HOGENOM; CLU_021483_0_0_1; -.
DR InParanoid; Q59MN0; -.
DR OMA; VWDKPDG; -.
DR OrthoDB; 688964at2759; -.
DR PRO; PR:Q59MN0; -.
DR Proteomes; UP000000559; Chromosome 4.
DR GO; GO:1903561; C:extracellular vesicle; IDA:CGD.
DR GO; GO:0000324; C:fungal-type vacuole; ISS:CGD.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IBA:GO_Central.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:0030448; P:hyphal growth; IMP:CGD.
DR GO; GO:0071562; P:nucleus-vacuole junction assembly; IBA:GO_Central.
DR GO; GO:0000011; P:vacuole inheritance; IMP:CGD.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR045156; Vac8.
DR PANTHER; PTHR47249; PTHR47249; 1.
DR Pfam; PF00514; Arm; 7.
DR SMART; SM00185; ARM; 9.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50176; ARM_REPEAT; 7.
PE 3: Inferred from homology;
KW Lipoprotein; Membrane; Myristate; Palmitate; Reference proteome; Repeat;
KW Vacuole.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..585
FT /note="Vacuolar protein 8"
FT /id="PRO_0000256208"
FT REPEAT 39..76
FT /note="ARM 1"
FT REPEAT 77..116
FT /note="ARM 2"
FT REPEAT 118..157
FT /note="ARM 3"
FT REPEAT 159..198
FT /note="ARM 4"
FT REPEAT 200..239
FT /note="ARM 5"
FT REPEAT 243..282
FT /note="ARM 6"
FT REPEAT 284..323
FT /note="ARM 7"
FT REPEAT 325..365
FT /note="ARM 8"
FT REPEAT 409..448
FT /note="ARM 9"
FT REGION 531..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250"
FT LIPID 4
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 5
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 7
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 585 AA; 63407 MW; 01FA4050F69A1649 CRC64;
MGACCSCLGN RGGDGSHTQL LLAENEREAI SALLQYLENR SDVDFFSNGP LRALSTLVYS
ENIDLQRSAA LAFAEITEKD VREVNRDVLE PILILLQSAD SEVQRAACGA LGNLAVNTEN
KILIVEMGGL EPLIRQMMST NIEVQCNAVG CITNLATQDD NKSKIAKSGA LIPLTKLAKS
KDIRVQRNAT GALLNMTHSG ENRQELVNAG AVPVLVSLLS NEDADVQYYC TTALSNIAVD
EVNRKKLAST EPKLVGQLVH LMDSPSPRVQ CQATLALRNL ASDSGYQVEI VRAGGLPHLV
QLLTCNHQPL VLAAVACIRN ISIHPLNEAL IIEAGFLKPL VGLLDYTDSE EIQCHAVSTL
RNLAASSEKN RTALLAAGAV DKCKELVLKV PLTVQSEISA CFAILALADD LKPKLYESHI
IDVLIPLTFS ENGEVCGNSA AALANLCSRV SNEHKQYILN NWAQPNEGIY GFLIRFLESG
SPTFEHIALW TILQLLESNN TEINALIKEN ETILAGIKNL SASQQQIQQS QIGQTTTTTT
TNITNNNTNT NTNTNTTTST SNEDQFEDPK VELFNLTQQI LQILG
