VAC8_CANGA
ID VAC8_CANGA Reviewed; 582 AA.
AC Q6FJV1;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Vacuolar protein 8;
GN Name=VAC8; OrderedLocusNames=CAGL0M03355g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Functions in both vacuole inheritance and protein targeting
CC from the cytoplasm to vacuole. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Lipid-anchor
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR EMBL; CR380959; CAG62469.1; -; Genomic_DNA.
DR RefSeq; XP_449493.1; XM_449493.1.
DR AlphaFoldDB; Q6FJV1; -.
DR SMR; Q6FJV1; -.
DR STRING; 5478.XP_449493.1; -.
DR EnsemblFungi; CAG62469; CAG62469; CAGL0M03355g.
DR GeneID; 2891501; -.
DR KEGG; cgr:CAGL0M03355g; -.
DR CGD; CAL0137157; CAGL0M03355g.
DR VEuPathDB; FungiDB:CAGL0M03355g; -.
DR eggNOG; KOG4224; Eukaryota.
DR HOGENOM; CLU_021483_0_0_1; -.
DR InParanoid; Q6FJV1; -.
DR OMA; VWDKPDG; -.
DR Proteomes; UP000002428; Chromosome M.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR GO; GO:0016021; C:integral component of membrane; IEA:EnsemblFungi.
DR GO; GO:0045121; C:membrane raft; IEA:EnsemblFungi.
DR GO; GO:0071563; C:Myo2p-Vac17p-Vac8p transport complex; IEA:EnsemblFungi.
DR GO; GO:0071561; C:nucleus-vacuole junction; IEA:EnsemblFungi.
DR GO; GO:0000407; C:phagophore assembly site; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IEA:EnsemblFungi.
DR GO; GO:0000045; P:autophagosome assembly; IEA:EnsemblFungi.
DR GO; GO:0071255; P:Cvt vesicle assembly; IEA:EnsemblFungi.
DR GO; GO:0071562; P:nucleus-vacuole junction assembly; IEA:EnsemblFungi.
DR GO; GO:0000425; P:pexophagy; IEA:EnsemblFungi.
DR GO; GO:1903044; P:protein localization to membrane raft; IEA:EnsemblFungi.
DR GO; GO:0034517; P:ribophagy; IEA:EnsemblFungi.
DR GO; GO:0042144; P:vacuole fusion, non-autophagic; IEA:EnsemblFungi.
DR GO; GO:0000011; P:vacuole inheritance; IEA:EnsemblFungi.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR045156; Vac8.
DR PANTHER; PTHR47249; PTHR47249; 1.
DR Pfam; PF00514; Arm; 8.
DR SMART; SM00185; ARM; 9.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 7.
PE 3: Inferred from homology;
KW Lipoprotein; Membrane; Myristate; Palmitate; Reference proteome; Repeat;
KW Vacuole.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..582
FT /note="Vacuolar protein 8"
FT /id="PRO_0000256209"
FT REPEAT 37..74
FT /note="ARM 1"
FT REPEAT 75..114
FT /note="ARM 2"
FT REPEAT 116..155
FT /note="ARM 3"
FT REPEAT 157..196
FT /note="ARM 4"
FT REPEAT 198..237
FT /note="ARM 5"
FT REPEAT 239..280
FT /note="ARM 6"
FT REPEAT 282..321
FT /note="ARM 7"
FT REPEAT 323..363
FT /note="ARM 8"
FT REPEAT 407..446
FT /note="ARM 9"
FT REGION 528..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..549
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250"
FT LIPID 4
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 5
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 7
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 582 AA; 63901 MW; CD39E0C773D870E3 CRC64;
MGGCCSCFRD SSDDVSVLPI TDNEREAVTL LLGYLEDKDR LDFYSGGPLK ALTTLVYSDN
LNLQRSAALA FAEVTEKYVR QVSRDVLEPI LILLQSQDPQ IQVAACAALG NLAVNNENKL
LIVDMGGLEP LINQMMGTNV EVQCNAVGCI TNLATRDDNK HKIATSGALV PLTKLAKSKH
IRVQRNATGA LLNMTHSEEN RRELVNAGAV PVLVSLLSSN DPDVQYYCTT ALSNIAVDEA
NRKKLAQTEP RLVSKLVSLM DSPSSRVKCQ ATLALRNLAS DTSYQLEIVR AGGLPHLVNL
IQSESVPLIL ASVACIRNIS IHPLNEGLIV DAGFLPPLVK LLDYRDSEEI QCHAVSTLRN
LAASSEKNRK EFFESGAVKK CKELALDSPV SVQSEISACF AILALADVSK QDLLDADILQ
ALIPMTFSTN QEVSGNAAAA LANLCSRIDN YSKIISSWDQ PKEGIRGFLK RFLQSNYATF
EHIALWAILQ LSESHNDKVI YLIKNDKEII NSVRKMADVT YDRLQKSGVD VNKNGNSEER
GDNEDHQSNN DRNLANSTSS DQYEDASMEL YNITQQILQF LD
