ID   VAC8_CHAGB              Reviewed;         560 AA.
AC   Q2GW27;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Vacuolar protein 8;
GN   Name=VAC8; ORFNames=CHGG_07827;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Functions in both vacuole inheritance and protein targeting
CC       from the cytoplasm to vacuole. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR   EMBL; CH408033; EAQ86574.1; -; Genomic_DNA.
DR   RefSeq; XP_001225483.1; XM_001225482.1.
DR   AlphaFoldDB; Q2GW27; -.
DR   SMR; Q2GW27; -.
DR   STRING; 38033.XP_001225483.1; -.
DR   EnsemblFungi; EAQ86574; EAQ86574; CHGG_07827.
DR   GeneID; 4393666; -.
DR   eggNOG; KOG4224; Eukaryota.
DR   HOGENOM; CLU_021483_0_0_1; -.
DR   InParanoid; Q2GW27; -.
DR   OMA; VWDKPDG; -.
DR   OrthoDB; 688964at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043495; F:protein-membrane adaptor activity; IEA:InterPro.
DR   GO; GO:0071562; P:nucleus-vacuole junction assembly; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR045156; Vac8.
DR   PANTHER; PTHR47249; PTHR47249; 1.
DR   Pfam; PF00514; Arm; 6.
DR   SMART; SM00185; ARM; 9.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 7.
PE   3: Inferred from homology;
KW   Lipoprotein; Membrane; Myristate; Palmitate; Reference proteome; Repeat;
KW   Vacuole.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..560
FT                   /note="Vacuolar protein 8"
FT                   /id="PRO_0000256210"
FT   REPEAT          39..76
FT                   /note="ARM 1"
FT   REPEAT          77..116
FT                   /note="ARM 2"
FT   REPEAT          118..157
FT                   /note="ARM 3"
FT   REPEAT          159..198
FT                   /note="ARM 4"
FT   REPEAT          200..239
FT                   /note="ARM 5"
FT   REPEAT          243..282
FT                   /note="ARM 6"
FT   REPEAT          284..323
FT                   /note="ARM 7"
FT   REPEAT          325..365
FT                   /note="ARM 8"
FT   REPEAT          409..448
FT                   /note="ARM 9"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250"
FT   LIPID           4
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   560 AA;  60841 MW;  B27FBCE4D9138471 CRC64;
     MGICSSSCCG GKSRDALYEN VLAENEREAV ADLLQYLENR AETDFFSGEP LRALSTLVYS
     DNIDLQRSAS LTFAEITERD VRAVDRDTLG PILFLLENSD IEVQRAASAA LGNLAVNTDN
     KVLIVQLGGL QPLIKQMMSP NVEVQCNAVG CITNLATHEE NKAKIARSGA LGPLTRLAKS
     KDMRVQRNAT GALLNMTHSD ENRQQLVNAG AIPVLVQLLS SSDVDVQYYC TTALSNIAVD
     ANNRRKLAET EQRLVQYLVN LTESSSPKVQ CQAALALRNL ASDEKYQLEI VQAHGLGPLL
     RLLRSSYLPL ILSAVACIRN ISIHPQNESP IIEAGFLKPL VDLLGSTDNE EIQCHAISTL
     RNLAASSDRN KSLVLEAGAV QKCKQLVLEV PVTVQSEMTA AIAVLALSDE LKTHLLELGV
     FDVLIPLTMS PSVEVQGNSA AALGNLSSKV GDYSIFVQNW MEPRDGIHGY LNRFLASGDA
     TFQHIAIWTL LQLLESEDKK LIGLIGKSDG VVDMIKQIAN RQMMESDNEA EDDDEGEVVN
     LAQRCLELLG QGGSKSHIEG