ID   VAC8_DEBHA              Reviewed;         560 AA.
AC   Q6BTZ4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 4.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Vacuolar protein 8;
GN   Name=VAC8; OrderedLocusNames=DEHA2C14762g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Functions in both vacuole inheritance and protein targeting
CC       from the cytoplasm to vacuole. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR   EMBL; CR382135; CAG86405.2; -; Genomic_DNA.
DR   RefSeq; XP_458325.2; XM_458325.1.
DR   AlphaFoldDB; Q6BTZ4; -.
DR   SMR; Q6BTZ4; -.
DR   STRING; 4959.XP_458325.2; -.
DR   EnsemblFungi; CAG86405; CAG86405; DEHA2C14762g.
DR   GeneID; 2900082; -.
DR   KEGG; dha:DEHA2C14762g; -.
DR   VEuPathDB; FungiDB:DEHA2C14762g; -.
DR   eggNOG; KOG4224; Eukaryota.
DR   HOGENOM; CLU_021483_0_0_1; -.
DR   InParanoid; Q6BTZ4; -.
DR   OMA; VWDKPDG; -.
DR   OrthoDB; 688964at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043495; F:protein-membrane adaptor activity; IEA:InterPro.
DR   GO; GO:0071562; P:nucleus-vacuole junction assembly; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR045156; Vac8.
DR   PANTHER; PTHR47249; PTHR47249; 1.
DR   Pfam; PF00514; Arm; 7.
DR   SMART; SM00185; ARM; 9.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 7.
PE   3: Inferred from homology;
KW   Lipoprotein; Membrane; Myristate; Palmitate; Reference proteome; Repeat;
KW   Vacuole.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..560
FT                   /note="Vacuolar protein 8"
FT                   /id="PRO_0000256212"
FT   REPEAT          39..76
FT                   /note="ARM 1"
FT   REPEAT          77..116
FT                   /note="ARM 2"
FT   REPEAT          118..157
FT                   /note="ARM 3"
FT   REPEAT          159..198
FT                   /note="ARM 4"
FT   REPEAT          200..239
FT                   /note="ARM 5"
FT   REPEAT          243..282
FT                   /note="ARM 6"
FT   REPEAT          284..323
FT                   /note="ARM 7"
FT   REPEAT          325..365
FT                   /note="ARM 8"
FT   REPEAT          409..448
FT                   /note="ARM 9"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250"
FT   LIPID           4
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   LIPID           5
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   LIPID           7
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   560 AA;  61077 MW;  B8B496801CADD601 CRC64;
     MGACCSCLCS RNRDSKYPPL LLAENEREAI SALLQYLENR SDVDFFSNGP LRALSTLVYS
     ENIDLQRSAA LAFAEITEKD VREVNRDVLE PILILLQSAD SEVQRAACGA LGNLAVNNEN
     KILIVEMGGL EPLIRQMMST NIEVQCNAVG CITNLATQDD NKTKIAKSGA LIPLAKLAKS
     KDIRVQRNAT GALLNMTHSG ENRQELVNAG AVPVLVSLLS NEDADVQYYC TTALSNIAVD
     EMNRKKLSTT EPKLVSQLVN LMDSPSPRVQ CQATLALRNL ASDSGYQVEI VRAGGLPHLV
     QLLTCNHQPL VLAAVACIRN ISIHPLNEAL IIDAGFLKPL VGLLDFNDSE EIQCHAVSTL
     RNLAASSERN RLALLAAGAV DKCKELVLKV PLSVQSEISA CFAILALADD LKPKLYESHI
     IDVLIPLTFS ENGEVCGNSA AALANLCSRV SSEHKQYIFK NWSEPNEGIY GFLLRFLQSG
     SATFEHIALW TILQLLESNN TEINSLIKEN ESILSGIKNL SASQQQTQQS QVNNPDSSDQ
     FDDPKVELFN LTQQILQILG