VAC8_GIBZE
ID VAC8_GIBZE Reviewed; 559 AA.
AC Q4I1B1; A0A0E0SCZ0; I1RXD1; V6RM33;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2012, sequence version 4.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Vacuolar protein 8;
GN Name=VAC8; ORFNames=FGRRES_08997, FGSG_08997;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Functions in both vacuole inheritance and protein targeting
CC from the cytoplasm to vacuole. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Lipid-anchor
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR EMBL; DS231668; ESU15511.1; -; Genomic_DNA.
DR EMBL; HG970335; CEF84303.1; -; Genomic_DNA.
DR RefSeq; XP_011328805.1; XM_011330503.1.
DR AlphaFoldDB; Q4I1B1; -.
DR SMR; Q4I1B1; -.
DR STRING; 5518.FGSG_08997P0; -.
DR EnsemblFungi; ESU15511; ESU15511; FGSG_08997.
DR GeneID; 23555966; -.
DR KEGG; fgr:FGSG_08997; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G28157; -.
DR eggNOG; KOG4224; Eukaryota.
DR HOGENOM; CLU_021483_0_0_1; -.
DR InParanoid; Q4I1B1; -.
DR Proteomes; UP000070720; Chromosome 4.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IEA:InterPro.
DR GO; GO:0071562; P:nucleus-vacuole junction assembly; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR045156; Vac8.
DR PANTHER; PTHR47249; PTHR47249; 1.
DR Pfam; PF00514; Arm; 7.
DR SMART; SM00185; ARM; 9.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 7.
PE 3: Inferred from homology;
KW Lipoprotein; Membrane; Myristate; Palmitate; Reference proteome; Repeat;
KW Vacuole.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..559
FT /note="Vacuolar protein 8"
FT /id="PRO_0000256213"
FT REPEAT 77..116
FT /note="ARM 1"
FT REPEAT 118..157
FT /note="ARM 2"
FT REPEAT 159..198
FT /note="ARM 3"
FT REPEAT 200..239
FT /note="ARM 4"
FT REPEAT 243..282
FT /note="ARM 5"
FT REPEAT 284..323
FT /note="ARM 6"
FT REPEAT 325..365
FT /note="ARM 7"
FT REPEAT 409..448
FT /note="ARM 8"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250"
FT LIPID 4
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 559 AA; 60829 MW; EA088797B83FA84F CRC64;
MGICSSTCCG GRARDGLYEP VLADSEREAV ADLLQYLENR GETDFFSGEP LRALSTLVFS
ENIDLQRSAS LTFAEITERD VREVDRDTLE PILFLLQSPD IEVQRAASAA LGNLAVDTEN
KVLIVQLGGL TPLIRQMMSP NVEVQCNAVG CITNLATHEE NKAKIARSGA LGPLTRLAKS
RDMRVQRNAT GALLNMTHSD ENRQQLVNAG AIPVLVQLLS SPDVDVQYYC TTALSNIAVD
ASNRRKLAQS EPKLVQSLVN LMDSTSPKVQ CQAALALRNL ASDEKYQLDI VRANGLHPLL
RLLQSSYLPL ILSAVACIRN ISIHPMNESP IIETNFLKPL VDLLGSTDNE EIQCHAISTL
RNLAASSDRN KALVLDAGAV QKCKQLVLDV PITVQSEMTA AIAVLALSDD LKSHLLNLGV
CGVLIPLTHS PSIEVQGNSA AALGNLSSKV GDYSIFVQNW TEPQGGIHGY LCRFLQSGDA
TFQHIAVWTL LQLFESEDKT LIGLIGKAED IIEHIRSIAN RQIEPDNEFE DEDEGEVVNL
AQRCLELLGQ SMSKAHIEG
