ID   VAC8_YARLI              Reviewed;         573 AA.
AC   Q6C5Y8;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Vacuolar protein 8;
GN   Name=VAC8; OrderedLocusNames=YALI0E13992g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Functions in both vacuole inheritance and protein targeting
CC       from the cytoplasm to vacuole. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG79517.1; -; Genomic_DNA.
DR   RefSeq; XP_503924.1; XM_503924.1.
DR   AlphaFoldDB; Q6C5Y8; -.
DR   SMR; Q6C5Y8; -.
DR   STRING; 4952.CAG79517; -.
DR   EnsemblFungi; CAG79517; CAG79517; YALI0_E13992g.
DR   GeneID; 2911494; -.
DR   KEGG; yli:YALI0E13992g; -.
DR   VEuPathDB; FungiDB:YALI0_E13992g; -.
DR   HOGENOM; CLU_021483_0_0_1; -.
DR   InParanoid; Q6C5Y8; -.
DR   OMA; VWDKPDG; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR   GO; GO:0043495; F:protein-membrane adaptor activity; IBA:GO_Central.
DR   GO; GO:0071562; P:nucleus-vacuole junction assembly; IBA:GO_Central.
DR   GO; GO:0000011; P:vacuole inheritance; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR045156; Vac8.
DR   PANTHER; PTHR47249; PTHR47249; 1.
DR   Pfam; PF00514; Arm; 8.
DR   SMART; SM00185; ARM; 9.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   PROSITE; PS50176; ARM_REPEAT; 7.
PE   3: Inferred from homology;
KW   Lipoprotein; Membrane; Reference proteome; Repeat; Vacuole.
FT   CHAIN           1..573
FT                   /note="Vacuolar protein 8"
FT                   /id="PRO_0000256218"
FT   REPEAT          60..97
FT                   /note="ARM 1"
FT   REPEAT          98..137
FT                   /note="ARM 2"
FT   REPEAT          139..178
FT                   /note="ARM 3"
FT   REPEAT          180..219
FT                   /note="ARM 4"
FT   REPEAT          221..260
FT                   /note="ARM 5"
FT   REPEAT          264..303
FT                   /note="ARM 6"
FT   REPEAT          305..344
FT                   /note="ARM 7"
FT   REPEAT          346..386
FT                   /note="ARM 8"
FT   REPEAT          430..469
FT                   /note="ARM 9"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   573 AA;  62134 MW;  C52DC5F41247D9F6 CRC64;
     MAASAADRMG RQRMSGLSCS APPRPTVVTN PGNKQDGNYA PVLAEDEREA VALLLRYLEN
     RGEVDFFSNG PLRALSTLVY SDNIDLQRSA ALAFAEITEK DIRPVNRDCL EPVLLLLQNT
     DPDIQRAASA ALGNLAVNNE NKVLIVEMGG FEPLIRQMMS PNVEVQCNAV GCITNLATHE
     ANKSKIARSG ALLPLTKLAK SKDMRVQRNA TGALLNMTHS DQNRQELVNA GAIPILVSLL
     SSRDPDVQYY STTALSNIAV DESNRKKLSS SEPRLVEHLI KLMDSGSPRV QCQAALALRN
     LASDSDYQLE IVKANGLPHL FNLFQSTHTP LVLAAVACIR NISIHPLNET PIIEAGFLKT
     LVELLGASDN EEIQCHTIST LRNLAASSER NKLEIVEAGA VQKCKELVLD APRLVQSEMT
     ACLAVLALGD ELKGTLLELG IAEVLIPLTL SDNIEVQGNS AAALGNLSSK VGNYDTFVNH
     WNEPSGGIRE FLIRFLTSGD STFGHIAVWT VLQLLESKDQ RLKDLLKNSN EIVDAIHQLS
     SMNSDGADGD GEDMRDSKSE VVMLAKKVAP LLK