ID   VACC_DICDI              Reviewed;         586 AA.
AC   Q54WZ3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Vacuolin-C;
GN   Name=vacC; ORFNames=DDB_G0279307;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the vacuolin family. {ECO:0000305}.
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DR   EMBL; AAFI02000030; EAL67802.1; -; Genomic_DNA.
DR   RefSeq; XP_641784.1; XM_636692.1.
DR   AlphaFoldDB; Q54WZ3; -.
DR   SMR; Q54WZ3; -.
DR   PaxDb; Q54WZ3; -.
DR   ABCD; Q54WZ3; 4 sequenced antibodies.
DR   EnsemblProtists; EAL67802; EAL67802; DDB_G0279307.
DR   GeneID; 8621981; -.
DR   KEGG; ddi:DDB_G0279307; -.
DR   dictyBase; DDB_G0279307; vacC.
DR   eggNOG; ENOG502S9G3; Eukaryota.
DR   HOGENOM; CLU_461128_0_0_1; -.
DR   InParanoid; Q54WZ3; -.
DR   OMA; FSINSHN; -.
DR   PhylomeDB; Q54WZ3; -.
DR   PRO; PR:Q54WZ3; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0032009; C:early phagosome; IDA:dictyBase.
DR   GO; GO:0016020; C:membrane; IDA:dictyBase.
DR   GO; GO:0061951; P:establishment of protein localization to plasma membrane; IGI:dictyBase.
DR   GO; GO:0006910; P:phagocytosis, recognition; IGI:dictyBase.
DR   GO; GO:0090382; P:phagosome maturation; IGI:dictyBase.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IGI:dictyBase.
DR   GO; GO:0009617; P:response to bacterium; HEP:dictyBase.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   Pfam; PF01145; Band_7; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..586
FT                   /note="Vacuolin-C"
FT                   /id="PRO_0000328357"
FT   COILED          472..526
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   586 AA;  65397 MW;  E484C9ECFA7411B4 CRC64;
     MIESKIPSQF SINSHNNVCE ASSYSDHSFD DNTQSIPLSQ VVIRSDFANE TSERQSKIII
     ERFNQGIKNP AFTDSPALGR AFPRLDSSYF ALSNRDKVAE LFDPRGQRFS TVYSADPTTI
     IEYNGGIPKT SRYFTLYGKT VLNVPSGHFA KALSKNRPVI YGEGPHVIID PTFIFDEATG
     FVNQQEPFIN HSTINVLRVP SGKVAKVWVG TQPLILESRR EPYVFVDAQF KVVEQIGSQD
     KYFHNSSATF MEHGSIKRII PHTGEVAVTY NNGVLEIIQT PKDGKPVIID SPTHNFECFI
     QTSLQTCLFP SNETKQQAIK DNKNATSDEV NLKIFQTRDS LRVGVVLVIA FRIIDPQIAL
     TKLGKEGIIN HIENISFADM GKAIQLSTLQ EIMYFNDTKP SATIDASAQT IQDRVKSHLA
     RDLYEYGIEL ARLQIETIKV LDTEIAKKLA GQSVTSAEFT TKQATLVKEY DIKTTEARLK
     AETDNIALEQ KGIAIIAEAQ AKLESAKKQA EALLVTANAQ KKVQEIQGEL YSKFPILAEI
     ELAKIKSEAL KSSTLYITPQ DAGNFMNSPF FFMERMLGKQ QTNIKS