ID   VAD2_HELPY              Reviewed;          95 AA.
AC   O25620;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Endoribonuclease VapD homolog;
DE            EC=3.1.-.-;
DE   AltName: Full=Virulence-associated protein D homolog;
GN   OrderedLocusNames=HP_0967;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Cleaves ssRNA, mostly between U:A. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- MISCELLANEOUS: There is no ortholog for HP0967 in strain J99.
CC   -!- SIMILARITY: Belongs to the VapD ribonuclease family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000511; AAD08011.1; -; Genomic_DNA.
DR   PIR; G64640; G64640.
DR   RefSeq; NP_207759.1; NC_000915.1.
DR   RefSeq; WP_000271456.1; NC_018939.1.
DR   AlphaFoldDB; O25620; -.
DR   SMR; O25620; -.
DR   IntAct; O25620; 2.
DR   STRING; 85962.C694_04980; -.
DR   PaxDb; O25620; -.
DR   EnsemblBacteria; AAD08011; AAD08011; HP_0967.
DR   KEGG; hpy:HP_0967; -.
DR   PATRIC; fig|85962.47.peg.1035; -.
DR   eggNOG; COG3309; Bacteria.
DR   OMA; CFGDETI; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   InterPro; IPR016368; VapD.
DR   InterPro; IPR019199; Virulence_VapD/CRISPR_Cas2.
DR   Pfam; PF09827; CRISPR_Cas2; 1.
DR   PIRSF; PIRSF002882; VapD; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Nuclease; Reference proteome; Virulence.
FT   CHAIN           1..95
FT                   /note="Endoribonuclease VapD homolog"
FT                   /id="PRO_0000217273"
SQ   SEQUENCE   95 AA;  10778 MW;  CC03BE7108D1F1C0 CRC64;
     MYAVTFDLDT NCLNENAVNL SKVYSDIRKF MEQHGFKWQQ GSVYFGDETI NAVTCVATVQ
     ILAKQIPSFA VCVKDVRMLK IEENNDLMPA IKIVL