ID   VAL5_VESMC              Reviewed;         227 AA.
AC   Q2L6Z1;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Venom allergen 5;
DE   AltName: Full=Antigen 5;
DE   AltName: Full=Cysteine-rich venom protein;
DE            Short=CRVP;
DE   Flags: Precursor;
OS   Vespula maculifrons (Eastern yellow jacket) (Wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Vespula.
OX   NCBI_TaxID=7453;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Zhang S., Shi W., Cheng J., Zhang C.;
RT   "Cloning and sequencing of genes encoding allergen 5 from the venom of
RT   Vespula maculifrons.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- ALLERGEN: Causes an allergic reaction in human. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ364142; ABC73068.1; -; mRNA.
DR   AlphaFoldDB; Q2L6Z1; -.
DR   SMR; Q2L6Z1; -.
DR   Allergome; 663; Ves m 5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   2: Evidence at transcript level;
KW   Allergen; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..227
FT                   /note="Venom allergen 5"
FT                   /id="PRO_0000401930"
FT   DOMAIN          68..212
FT                   /note="SCP"
FT   DISULFID        27..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..124
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..117
FT                   /evidence="ECO:0000250"
FT   DISULFID        193..210
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   227 AA;  25832 MW;  10BD801948485E63 CRC64;
     MEISGLVYLI IIVTIIDLPY GKANNYCKIK CLKGGVHTAC KYGSLKPNCG NKVVVSYGLT
     KQEKQDILKE HNDFRQKVAR GLETRGNPGP QPPAKNMKNL VWNDELAYVA QVWANQCQYG
     HDTCRDVAKY QVGQNVALTG STAAKYENPV NLVKMWENEV KDYNPKKKFS ENNFIKIGHY
     TQMVWANTKE IGCGSMKYTE NKWHYHYLVC NYGPSGNFGN EELYQTK