VAM7_SCHPO
ID VAM7_SCHPO Reviewed; 341 AA.
AC O74509;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Vacuolar morphogenesis protein 7 homolog;
GN ORFNames=SPCC594.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Essential for proper morphogenesis of the vacuole. May exist
CC as structural reinforcement on the surface of the vacuolar membrane and
CC be required for maintenance against rupture by osmotic pressure (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Possibly multimeric. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329672; CAA20665.1; -; Genomic_DNA.
DR PIR; T41450; T41450.
DR RefSeq; NP_587792.1; NM_001022785.2.
DR AlphaFoldDB; O74509; -.
DR SMR; O74509; -.
DR BioGRID; 275428; 75.
DR STRING; 4896.SPCC594.06c.1; -.
DR iPTMnet; O74509; -.
DR MaxQB; O74509; -.
DR PaxDb; O74509; -.
DR PRIDE; O74509; -.
DR EnsemblFungi; SPCC594.06c.1; SPCC594.06c.1:pep; SPCC594.06c.
DR GeneID; 2538847; -.
DR KEGG; spo:SPCC594.06c; -.
DR PomBase; SPCC594.06c; -.
DR VEuPathDB; FungiDB:SPCC594.06c; -.
DR eggNOG; ENOG502RXJQ; Eukaryota.
DR HOGENOM; CLU_033748_2_0_1; -.
DR InParanoid; O74509; -.
DR OMA; NITMMRI; -.
DR PhylomeDB; O74509; -.
DR PRO; PR:O74509; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:PomBase.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005770; C:late endosome; IDA:PomBase.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; ISM:PomBase.
DR GO; GO:0005484; F:SNAP receptor activity; ISO:PomBase.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0006896; P:Golgi to vacuole transport; IGI:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEP:PomBase.
DR GO; GO:0097576; P:vacuole fusion; IGI:PomBase.
DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; ISO:PomBase.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; PTHR19957; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 3: Inferred from homology;
KW Coiled coil; Reference proteome; Vacuole.
FT CHAIN 1..341
FT /note="Vacuolar morphogenesis protein 7 homolog"
FT /id="PRO_0000339882"
FT DOMAIN 1..115
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT DOMAIN 278..340
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT REGION 214..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 341 AA; 38848 MW; 9BB2A35FE2C67FB4 CRC64;
MALKIKIPET SQSSDEYSRW TVYHIEVAFP NGGKHVVFRR FNEFVALDAQ IRPNDYNSRL
CKLPSKSWVS STVTNEKLRE SRRLALQAYV QCLSETPWIK MPVVKKFLNI KDESEDETQG
QFLGPTDWIQ VFQDCKRNLH MYRVDLMSGK SITIGVQTKN VYAIKSLMDN LSESLDKLEL
ANALGPGEIL RRKDMLEQLG SEFLSFKRLV KNANSPVAPP SASSQLNSSN PSSPFRPLSA
STDKQSNTSL NRVLGKNRMP ETQTTKKLDN VGLYNMQNQT MEDQDMQAES LLPIIQRQKE
LSKMINQEVV EQNSMLDELS NEAYANQKKL HRTRAGLRKL G
