ID   VAMP1_BOVIN             Reviewed;         118 AA.
AC   Q0V7N0; A4IFF1;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Vesicle-associated membrane protein 1;
DE            Short=VAMP-1;
DE   AltName: Full=Synaptobrevin-1;
GN   Name=VAMP1; Synonyms=SYB1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the targeting and/or fusion of transport vesicles
CC       to their target membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with VAPA and VAPB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory
CC       vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type IV
CC       membrane protein {ECO:0000250}. Synapse, synaptosome.
CC   -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasmic vesicle membrane
CC       {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
CC       Synapse, synaptosome.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q0V7N0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q0V7N0-2; Sequence=VSP_029184;
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR   EMBL; BT026540; ABH06327.1; -; mRNA.
DR   EMBL; BC134553; AAI34554.1; -; mRNA.
DR   RefSeq; NP_001069098.2; NM_001075630.2. [Q0V7N0-1]
DR   AlphaFoldDB; Q0V7N0; -.
DR   SMR; Q0V7N0; -.
DR   STRING; 9913.ENSBTAP00000019599; -.
DR   PaxDb; Q0V7N0; -.
DR   PRIDE; Q0V7N0; -.
DR   Ensembl; ENSBTAT00000019599; ENSBTAP00000019599; ENSBTAG00000014603. [Q0V7N0-1]
DR   GeneID; 513621; -.
DR   KEGG; bta:513621; -.
DR   CTD; 6843; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014603; -.
DR   eggNOG; KOG0860; Eukaryota.
DR   GeneTree; ENSGT00940000161390; -.
DR   HOGENOM; CLU_064620_4_0_1; -.
DR   InParanoid; Q0V7N0; -.
DR   OMA; WESPRIF; -.
DR   OrthoDB; 1606985at2759; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000014603; Expressed in midbrain and 104 other tissues.
DR   ExpressionAtlas; Q0V7N0; baseline and differential.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0035493; P:SNARE complex assembly; IBA:GO_Central.
DR   GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR   InterPro; IPR001388; Synaptobrevin.
DR   InterPro; IPR016444; Synaptobrevin/VAMP.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   PANTHER; PTHR45701; PTHR45701; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   PIRSF; PIRSF005409; Synaptobrevin_euk; 1.
DR   PRINTS; PR00219; SYNAPTOBREVN.
DR   PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Coiled coil; Cytoplasmic vesicle; Membrane;
KW   Phosphoprotein; Reference proteome; Synapse; Synaptosome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..118
FT                   /note="Vesicle-associated membrane protein 1"
FT                   /id="PRO_0000273714"
FT   TOPO_DOM        1..96
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..116
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        117..118
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          33..93
FT                   /note="v-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         63
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q62442"
FT   VAR_SEQ         114..118
FT                   /note="IYFFA -> SKYR (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16305752"
FT                   /id="VSP_029184"
FT   CONFLICT        54
FT                   /note="K -> E (in Ref. 1; ABH06327)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   118 AA;  12860 MW;  3711260AEECB6EB0 CRC64;
     MSAPAQPPTE GAEGAAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIMRV NVDKVLERDQ
     KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM LGAICAIIVV VIVIYFFA