ID   VAMP3_MACFA             Reviewed;         100 AA.
AC   Q4R8T0;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Vesicle-associated membrane protein 3;
DE            Short=VAMP-3;
DE   AltName: Full=Synaptobrevin-3;
GN   Name=VAMP3; Synonyms=SYB3; ORFNames=QtsA-11548;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: SNARE involved in vesicular transport from the late endosomes
CC       to the trans-Golgi network. {ECO:0000250|UniProtKB:Q15836}.
CC   -!- SUBUNIT: Interacts with BVES (via the C-terminus cytoplasmic tail).
CC       Interacts with BCAP31; involved in VAMP3 export from the endoplasmic
CC       reticulum (By similarity). Interacts with BAIAP3; this interaction is
CC       increased in the presence of calcium (By similarity). Interacts with
CC       PICALM (By similarity). {ECO:0000250|UniProtKB:P63024,
CC       ECO:0000250|UniProtKB:Q15836}.
CC   -!- SUBCELLULAR LOCATION: Early endosome membrane
CC       {ECO:0000250|UniProtKB:Q15836}; Single-pass type IV membrane protein
CC       {ECO:0000255}. Recycling endosome membrane
CC       {ECO:0000250|UniProtKB:Q15836}; Single-pass type I membrane protein
CC       {ECO:0000255}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q15836}.
CC   -!- PTM: Ubiquitinated by RNF167 at Lys-66, Lys-68 and Lys-77, regulating
CC       the recycling endosome pathway. {ECO:0000250|UniProtKB:Q15836}.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB168368; BAE00491.1; -; mRNA.
DR   RefSeq; NP_001270117.1; NM_001283188.1.
DR   AlphaFoldDB; Q4R8T0; -.
DR   SMR; Q4R8T0; -.
DR   STRING; 9541.XP_005544957.1; -.
DR   Ensembl; ENSMFAT00000079358; ENSMFAP00000055694; ENSMFAG00000048362.
DR   GeneID; 101866513; -.
DR   CTD; 9341; -.
DR   VEuPathDB; HostDB:ENSMFAG00000001731; -.
DR   eggNOG; KOG0860; Eukaryota.
DR   GeneTree; ENSGT00940000158192; -.
DR   OMA; MKMWGIL; -.
DR   OrthoDB; 1614157at2759; -.
DR   Proteomes; UP000233100; Chromosome 1.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0001921; P:positive regulation of receptor recycling; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISS:UniProtKB.
DR   GO; GO:0034446; P:substrate adhesion-dependent cell spreading; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR001388; Synaptobrevin.
DR   InterPro; IPR016444; Synaptobrevin/VAMP.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   PANTHER; PTHR45701; PTHR45701; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   PIRSF; PIRSF005409; Synaptobrevin_euk; 1.
DR   PRINTS; PR00219; SYNAPTOBREVN.
DR   PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   3: Inferred from homology;
KW   Acetylation; Coiled coil; Endosome; Isopeptide bond; Membrane;
KW   Protein transport; Reference proteome; Synapse; Synaptosome; Transmembrane;
KW   Transmembrane helix; Transport; Ubl conjugation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q15836"
FT   CHAIN           2..100
FT                   /note="Vesicle-associated membrane protein 3"
FT                   /id="PRO_0000273719"
FT   TOPO_DOM        2..77
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..100
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          14..74
FT                   /note="v-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15836"
FT   CROSSLNK        66
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000250|UniProtKB:Q15836"
FT   CROSSLNK        68
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000250|UniProtKB:Q15836"
FT   CROSSLNK        77
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000250|UniProtKB:Q15836"
SQ   SEQUENCE   100 AA;  11319 MW;  32D4516751624D06 CRC64;
     MSTGPTAAPG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA DALQAGASQF
     ETSAAKLKRK YWWKNCKMWA IGITVLLIFI IIIIVWVVSS