ID   VAMP5_BOVIN             Reviewed;         116 AA.
AC   Q2KHY2;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Vesicle-associated membrane protein 5;
DE            Short=VAMP-5;
GN   Name=VAMP5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May participate in trafficking events that are associated
CC       with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}. Endomembrane system {ECO:0000305};
CC       Single-pass type IV membrane protein {ECO:0000305}. Golgi apparatus,
CC       trans-Golgi network membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}. Note=Associated with the plasma
CC       membrane as well as intracellular perinuclear and peripheral vesicular
CC       structures of myotubes. Associated with the trans-Golgi, but not with
CC       the cis-Golgi apparatus (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR   EMBL; BC112840; AAI12841.1; -; mRNA.
DR   RefSeq; NP_001039941.1; NM_001046476.1.
DR   AlphaFoldDB; Q2KHY2; -.
DR   SMR; Q2KHY2; -.
DR   STRING; 9913.ENSBTAP00000024333; -.
DR   PaxDb; Q2KHY2; -.
DR   Ensembl; ENSBTAT00000024333; ENSBTAP00000024333; ENSBTAG00000018285.
DR   GeneID; 540406; -.
DR   KEGG; bta:540406; -.
DR   CTD; 10791; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018285; -.
DR   VGNC; VGNC:36759; VAMP5.
DR   eggNOG; KOG0860; Eukaryota.
DR   GeneTree; ENSGT00730000111371; -.
DR   HOGENOM; CLU_064620_4_2_1; -.
DR   InParanoid; Q2KHY2; -.
DR   OMA; VRCRIYL; -.
DR   OrthoDB; 1607213at2759; -.
DR   TreeFam; TF313666; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000018285; Expressed in tongue muscle and 105 other tissues.
DR   ExpressionAtlas; Q2KHY2; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0043001; P:Golgi to plasma membrane protein transport; IBA:GO_Central.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   CDD; cd15872; R-SNARE_VAMP5; 1.
DR   InterPro; IPR001388; Synaptobrevin.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   InterPro; IPR042166; Vamp5.
DR   InterPro; IPR042581; VAMP5_R-SNARE.
DR   PANTHER; PTHR47462; PTHR47462; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   PRINTS; PR00219; SYNAPTOBREVN.
DR   PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Coiled coil; Developmental protein; Differentiation;
KW   Golgi apparatus; Membrane; Myogenesis; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..116
FT                   /note="Vesicle-associated membrane protein 5"
FT                   /id="PRO_0000273717"
FT   TOPO_DOM        1..72
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..116
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          5..65
FT                   /note="v-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT   REGION          97..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         41
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Z2P8"
FT   MOD_RES         48
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O95183"
FT   MOD_RES         49
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O95183"
SQ   SEQUENCE   116 AA;  12778 MW;  7FD1E7157586862E CRC64;
     MAGKELERCQ RQADEVTEIM LNNFDKVLER DGKLAELEQR SDQLLDMSSA FSKTTKTLAQ
     KKRWENARCR IYMGLAVGIA LLILLIVLLV IFLPQSSKGS SAPQVQDAGP ASGPGE