ID   VAMP5_RAT               Reviewed;         102 AA.
AC   Q9Z2J5;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 133.
DE   RecName: Full=Vesicle-associated membrane protein 5;
DE            Short=VAMP-5;
DE   AltName: Full=Myobrevin;
GN   Name=Vamp5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9725904; DOI=10.1091/mbc.9.9.2423;
RA   Zeng Q., Subramaniam V.N., Wong S.H., Tang B.L., Parton R.G., Rea S.,
RA   James D.E., Hong W.;
RT   "A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during
RT   in vitro myogenesis and present in the plasma membrane.";
RL   Mol. Biol. Cell 9:2423-2437(1998).
CC   -!- FUNCTION: May participate in trafficking events that are associated
CC       with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}. Endomembrane system {ECO:0000305};
CC       Single-pass type IV membrane protein {ECO:0000305}. Golgi apparatus,
CC       trans-Golgi network membrane {ECO:0000305}; Single-pass type IV
CC       membrane protein {ECO:0000305}. Note=Associated with the plasma
CC       membrane as well as intracellular perinuclear and peripheral vesicular
CC       structures of myotubes. Associated with the trans-Golgi, but not with
CC       the cis-Golgi apparatus (By similarity). {ECO:0000250}.
CC   -!- INDUCTION: During myogenesis.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR   EMBL; AF054826; AAC97474.1; -; mRNA.
DR   RefSeq; NP_446007.1; NM_053555.1.
DR   AlphaFoldDB; Q9Z2J5; -.
DR   SMR; Q9Z2J5; -.
DR   BioGRID; 250141; 1.
DR   STRING; 10116.ENSRNOP00000016984; -.
DR   iPTMnet; Q9Z2J5; -.
DR   PhosphoSitePlus; Q9Z2J5; -.
DR   PaxDb; Q9Z2J5; -.
DR   GeneID; 89818; -.
DR   KEGG; rno:89818; -.
DR   UCSC; RGD:620419; rat.
DR   CTD; 10791; -.
DR   RGD; 620419; Vamp5.
DR   eggNOG; KOG0860; Eukaryota.
DR   HOGENOM; CLU_064620_4_2_1; -.
DR   InParanoid; Q9Z2J5; -.
DR   OrthoDB; 1607213at2759; -.
DR   PhylomeDB; Q9Z2J5; -.
DR   PRO; PR:Q9Z2J5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q9Z2J5; RN.
DR   GO; GO:0009986; C:cell surface; ISO:RGD.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISO:RGD.
DR   GO; GO:0031301; C:integral component of organelle membrane; ISO:RGD.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISO:RGD.
DR   GO; GO:0014704; C:intercalated disc; ISO:RGD.
DR   GO; GO:0005770; C:late endosome; ISO:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR   GO; GO:0005802; C:trans-Golgi network; IDA:RGD.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0043001; P:Golgi to plasma membrane protein transport; ISO:RGD.
DR   GO; GO:0007519; P:skeletal muscle tissue development; ISO:RGD.
DR   CDD; cd15872; R-SNARE_VAMP5; 1.
DR   InterPro; IPR001388; Synaptobrevin.
DR   InterPro; IPR016444; Synaptobrevin/VAMP.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   InterPro; IPR042166; Vamp5.
DR   InterPro; IPR042581; VAMP5_R-SNARE.
DR   PANTHER; PTHR47462; PTHR47462; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   PIRSF; PIRSF005409; Synaptobrevin_euk; 1.
DR   PRINTS; PR00219; SYNAPTOBREVN.
DR   PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Developmental protein; Differentiation;
KW   Golgi apparatus; Membrane; Myogenesis; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..102
FT                   /note="Vesicle-associated membrane protein 5"
FT                   /id="PRO_0000206735"
FT   TOPO_DOM        1..72
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..102
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          5..65
FT                   /note="v-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT   MOD_RES         41
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Z2P8"
FT   MOD_RES         48
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O95183"
FT   MOD_RES         49
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O95183"
SQ   SEQUENCE   102 AA;  11495 MW;  6AC37413597236BC CRC64;
     MAGKELERCQ RQADQVTEIM LNNFDKVLER DGKLSELQQR SDQLLDMSSA FSKTTKTLAQ
     QKRWENIRCR VYLGLAVAGG LLLILVVLLV IFLPSGEDSS KP