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VAMP7_BOVIN
ID   VAMP7_BOVIN             Reviewed;         220 AA.
AC   Q17QI5;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Vesicle-associated membrane protein 7;
DE            Short=VAMP-7;
DE   AltName: Full=Synaptobrevin-like protein 1;
GN   Name=VAMP7; Synonyms=SYBL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the targeting and/or fusion of transport vesicles
CC       to their target membrane during transport of proteins from the early
CC       endosome to the lysosome. Required for heterotypic fusion of late
CC       endosomes with lysosomes and homotypic lysosomal fusion. Required for
CC       calcium regulated lysosomal exocytosis. Involved in the export of
CC       chylomicrons from the endoplasmic reticulum to the cis Golgi. Required
CC       for exocytosis of mediators during eosinophil and neutrophil
CC       degranulation, and target cell killing by natural killer cells.
CC       Required for focal exocytosis of late endocytic vesicles during
CC       phagosome formation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SNARE complex composed of STX4, SNAP23 and
CC       VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the
CC       SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required
CC       for heterotypic fusion of late endosomes with lysosomes. May interact
CC       with STX17 (By similarity). Interacts with PICALM (By similarity).
CC       Interacts with RAB21 (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:P51809}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC       {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
CC       Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-
CC       pass type IV membrane protein {ECO:0000250}. Late endosome membrane
CC       {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
CC       Lysosome membrane {ECO:0000250}; Single-pass type IV membrane protein
CC       {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-
CC       pass type IV membrane protein {ECO:0000250}. Cytoplasmic vesicle,
CC       phagosome membrane {ECO:0000250}; Single-pass type IV membrane protein
CC       {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=In immature
CC       neurons expression is localized in vesicular structures in axons and
CC       dendrites while in mature neurons it is localized to the
CC       somatodendritic region. Colocalizes with LAMP1 in kidney cells.
CC       Localization to the endoplasmic reticulum membrane was observed in the
CC       intestine but not in liver or kidney (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR   EMBL; BC118341; AAI18342.1; -; mRNA.
DR   RefSeq; NP_001069770.1; NM_001076302.1.
DR   AlphaFoldDB; Q17QI5; -.
DR   BMRB; Q17QI5; -.
DR   SMR; Q17QI5; -.
DR   PRIDE; Q17QI5; -.
DR   GeneID; 613984; -.
DR   KEGG; bta:613984; -.
DR   CTD; 6845; -.
DR   InParanoid; Q17QI5; -.
DR   OrthoDB; 1211929at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR   GO; GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031201; C:SNARE complex; ISS:UniProtKB.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0017156; P:calcium-ion regulated exocytosis; ISS:UniProtKB.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR   GO; GO:0043308; P:eosinophil degranulation; ISS:UniProtKB.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0043312; P:neutrophil degranulation; ISS:UniProtKB.
DR   GO; GO:0006911; P:phagocytosis, engulfment; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006906; P:vesicle fusion; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
DR   CDD; cd14824; Longin; 1.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR010908; Longin_dom.
DR   InterPro; IPR001388; Synaptobrevin.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   Pfam; PF13774; Longin; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   PRINTS; PR00219; SYNAPTOBREVN.
DR   SMART; SM01270; Longin; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
DR   PROSITE; PS50859; LONGIN; 1.
DR   PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Cytoplasmic vesicle; Endoplasmic reticulum;
KW   Endosome; Exocytosis; Golgi apparatus; Lysosome; Membrane; Phosphoprotein;
KW   Protein transport; Reference proteome; Signal-anchor; Synapse; Synaptosome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P51809"
FT   CHAIN           2..220
FT                   /note="Vesicle-associated membrane protein 7"
FT                   /id="PRO_0000284056"
FT   TOPO_DOM        2..188
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210..220
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          7..110
FT                   /note="Longin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT   DOMAIN          125..185
FT                   /note="v-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P51809"
FT   MOD_RES         167
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P51809"
FT   MOD_RES         168
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70280"
SQ   SEQUENCE   220 AA;  24962 MW;  2DEB4AC581C74A83 CRC64;
     MAILFAVVAR GTTILAKHAW CGGNFLEVTE QILAKIPSEN NKLTYSHGNY LFHYICQDRI
     VYLCITDDDF ERSRAFNFLN EIKKRFQTTY GSRAQTALPY AMNSEFSSVL AAQLKHHSEN
     KGLDKVMETQ AQVDELKGIM VRNIDLVAQR GERLELLIDK TENLVDSSVT FKTTSRNLAR
     AMCMKNLKLT IIIIIISVVF IYIIVSPLCG GFTWPNCVKK
 
 
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