VAMP7_CHICK
ID VAMP7_CHICK Reviewed; 220 AA.
AC Q5ZL74;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Vesicle-associated membrane protein 7;
DE AltName: Full=Synaptobrevin-like protein 1;
GN Name=VAMP7 {ECO:0000250|UniProtKB:P51809};
GN Synonyms=SYBL1 {ECO:0000250|UniProtKB:P51809}; ORFNames=RCJMB04_7f19;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000312|EMBL:CAG31519.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB {ECO:0000312|EMBL:CAG31519.1};
RC TISSUE=Bursa of Fabricius {ECO:0000305, ECO:0000312|EMBL:CAG31519.1};
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Involved in the targeting and/or fusion of transport vesicles
CC to their target membrane during transport of proteins from the early
CC endosome to the lysosome. Required for heterotypic fusion of late
CC endosomes with lysosomes and homotypic lysosomal fusion. Required for
CC calcium regulated lysosomal exocytosis. Involved in the export of
CC chylomicrons from the endoplasmic reticulum to the cis Golgi. Required
CC for focal exocytosis of late endocytic vesicles during phagosome
CC formation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000250|UniProtKB:P51809, ECO:0000250|UniProtKB:P70280,
CC ECO:0000250|UniProtKB:Q9JHW5, ECO:0000255}; Single-pass type IV
CC membrane protein {ECO:0000250|UniProtKB:P51809,
CC ECO:0000250|UniProtKB:P70280, ECO:0000250|UniProtKB:Q9JHW5,
CC ECO:0000255}. Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250|UniProtKB:P51809, ECO:0000250|UniProtKB:P70280,
CC ECO:0000250|UniProtKB:Q9JHW5, ECO:0000255}; Single-pass type IV
CC membrane protein {ECO:0000250|UniProtKB:P51809,
CC ECO:0000250|UniProtKB:P70280, ECO:0000250|UniProtKB:Q9JHW5,
CC ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:P51809,
CC ECO:0000250|UniProtKB:P70280, ECO:0000250|UniProtKB:Q9JHW5,
CC ECO:0000255}; Single-pass type IV membrane protein
CC {ECO:0000250|UniProtKB:P51809, ECO:0000250|UniProtKB:P70280,
CC ECO:0000250|UniProtKB:Q9JHW5, ECO:0000255}. Lysosome membrane
CC {ECO:0000250|UniProtKB:P51809, ECO:0000250|UniProtKB:P70280,
CC ECO:0000250|UniProtKB:Q9JHW5, ECO:0000255}; Single-pass type IV
CC membrane protein {ECO:0000250|UniProtKB:P51809,
CC ECO:0000250|UniProtKB:P70280, ECO:0000250|UniProtKB:Q9JHW5,
CC ECO:0000255}. Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P51809, ECO:0000250|UniProtKB:P70280,
CC ECO:0000250|UniProtKB:Q9JHW5, ECO:0000255}; Single-pass type IV
CC membrane protein {ECO:0000250|UniProtKB:P51809,
CC ECO:0000250|UniProtKB:P70280, ECO:0000250|UniProtKB:Q9JHW5,
CC ECO:0000255}. Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000250|UniProtKB:P51809, ECO:0000250|UniProtKB:P70280,
CC ECO:0000250|UniProtKB:Q9JHW5, ECO:0000255}; Single-pass type IV
CC membrane protein {ECO:0000250|UniProtKB:P51809,
CC ECO:0000250|UniProtKB:P70280, ECO:0000250|UniProtKB:Q9JHW5,
CC ECO:0000255}. Synapse, synaptosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000255}.
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DR EMBL; AJ719860; CAG31519.1; -; mRNA.
DR RefSeq; NP_001026292.1; NM_001031121.1.
DR RefSeq; XP_015133771.1; XM_015278285.1.
DR RefSeq; XP_015133772.1; XM_015278286.1.
DR RefSeq; XP_015133773.1; XM_015278287.1.
DR RefSeq; XP_015133774.1; XM_015278288.1.
DR RefSeq; XP_015133775.1; XM_015278289.1.
DR AlphaFoldDB; Q5ZL74; -.
DR BMRB; Q5ZL74; -.
DR SMR; Q5ZL74; -.
DR STRING; 9031.ENSGALP00000031702; -.
DR PaxDb; Q5ZL74; -.
DR Ensembl; ENSGALT00000032338; ENSGALP00000031702; ENSGALG00000007476.
DR Ensembl; ENSGALT00000087818; ENSGALP00000059872; ENSGALG00000007476.
DR GeneID; 422297; -.
DR KEGG; gga:422297; -.
DR CTD; 6845; -.
DR VEuPathDB; HostDB:geneid_422297; -.
DR eggNOG; KOG0859; Eukaryota.
DR GeneTree; ENSGT00510000047733; -.
DR HOGENOM; CLU_064620_1_1_1; -.
DR InParanoid; Q5ZL74; -.
DR OMA; NTKLMIM; -.
DR OrthoDB; 1211929at2759; -.
DR PhylomeDB; Q5ZL74; -.
DR Reactome; R-GGA-432720; Lysosome Vesicle Biogenesis.
DR Reactome; R-GGA-432722; Golgi Associated Vesicle Biogenesis.
DR Reactome; R-GGA-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-GGA-8856828; Clathrin-mediated endocytosis.
DR PRO; PR:Q5ZL74; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000007476; Expressed in spermatid and 14 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR GO; GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031201; C:SNARE complex; ISS:UniProtKB.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0017156; P:calcium-ion regulated exocytosis; ISS:UniProtKB.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.
DR GO; GO:0043308; P:eosinophil degranulation; ISS:UniProtKB.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0043312; P:neutrophil degranulation; ISS:UniProtKB.
DR GO; GO:0006911; P:phagocytosis, engulfment; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006906; P:vesicle fusion; ISS:UniProtKB.
DR GO; GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR001388; Synaptobrevin.
DR InterPro; IPR042855; V_SNARE_CC.
DR Pfam; PF13774; Longin; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
DR PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasmic vesicle; Endoplasmic reticulum; Endosome;
KW Golgi apparatus; Lysosome; Membrane; Protein transport; Reference proteome;
KW Signal-anchor; Synapse; Synaptosome; Transmembrane; Transmembrane helix;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P51809"
FT CHAIN 2..220
FT /note="Vesicle-associated membrane protein 7"
FT /evidence="ECO:0000250|UniProtKB:P51809"
FT /id="PRO_0000319995"
FT TOPO_DOM 2..188
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P51809, ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..220
FT /note="Vesicular"
FT /evidence="ECO:0000250|UniProtKB:P51809, ECO:0000255"
FT DOMAIN 7..110
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT DOMAIN 125..185
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
SQ SEQUENCE 220 AA; 24682 MW; D08834367BD53CA0 CRC64;
MAILFAVVAR GTTILAKHAW CGGNFLEVTE QILAKIPSEN NKLTYSHGNY LFHYICQDRI
IYLCITDDDF ERSRAFNFLN EIKKRFQTTY GSRAQTALPY AMNSEFSSVL AAQLKYHSES
KGTDQVAETQ AQVDELKGIM VRNIDLVAQR GEKLELLIDK TENLVDSSVT FKTTSRNLAR
AMCMKNLKLT IIIIIVSIVI IYIIVSAACG GLAWPSCVQK
