ID   VANI_VIBAN              Reviewed;         193 AA.
AC   P74945;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Acyl-homoserine-lactone synthase;
DE            EC=2.3.1.184;
DE   AltName: Full=Autoinducer synthesis protein VanI;
GN   Name=vanI;
OS   Vibrio anguillarum (Listonella anguillarum).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=55601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NB10 / Serotype O1;
RX   PubMed=9139920; DOI=10.1128/jb.179.9.3004-3012.1997;
RA   Milton D.L., Hardman A., Camara M., Chhabra S.R., Bycroft B.W.,
RA   Stewart G.S.A.B., Williams P.;
RT   "Quorum sensing in Vibrio anguillarum: characterization of the vanI/vanR
RT   locus and identification of the autoinducer N-(3-oxodecanoyl)-L-homoserine
RT   lactone.";
RL   J. Bacteriol. 179:3004-3012(1997).
CC   -!- FUNCTION: Required for the synthesis of N-(3-oxodecanoyl)-L-homoserine
CC       lactone (ODHL), an autoinducer molecule which binds to VanR.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-
CC         homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine;
CC         Xref=Rhea:RHEA:10096, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:55474,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651;
CC         EC=2.3.1.184;
CC   -!- SIMILARITY: Belongs to the autoinducer synthase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00533}.
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DR   EMBL; U69677; AAC45212.1; -; Genomic_DNA.
DR   RefSeq; WP_013868065.1; NZ_VSLF01000016.1.
DR   AlphaFoldDB; P74945; -.
DR   SMR; P74945; -.
DR   STRING; 55601.VANGNB10_cII0862c; -.
DR   GeneID; 63948384; -.
DR   OMA; YMLKDTF; -.
DR   OrthoDB; 1725271at2; -.
DR   GO; GO:0061579; F:N-acyl homoserine lactone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:1901336; P:lactone biosynthetic process; IMP:CACAO.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR018311; Autoind_synth_CS.
DR   InterPro; IPR001690; Autoind_synthase.
DR   PANTHER; PTHR39322; PTHR39322; 1.
DR   Pfam; PF00765; Autoind_synth; 1.
DR   PRINTS; PR01549; AUTOINDCRSYN.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS00949; AUTOINDUCER_SYNTH_1; 1.
DR   PROSITE; PS51187; AUTOINDUCER_SYNTH_2; 1.
PE   3: Inferred from homology;
KW   Autoinducer synthesis; Quorum sensing; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..193
FT                   /note="Acyl-homoserine-lactone synthase"
FT                   /id="PRO_0000210901"
SQ   SEQUENCE   193 AA;  22127 MW;  238E760CD8701188 CRC64;
     MTISIYSHTF QSVPQADYVS LLKLRYKVFS QRLQWELKTN RGMETDEYDV PEAHYLYAKE
     EQGHLVGCWR ILPTTSRYML KDTFSELLGV QQAPKAKEIY ELSRFAVDKD HSAQLGGVSN
     VTLQMFQSLY HHAQQYHINA YVTVTSASVE KLIKRMGIPC ERLGDKKVHL LGSTRSVALH
     IPMNEAYRAS VNA