ID   VANM_VIBAN              Reviewed;         400 AA.
AC   Q9FDA3;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Acyl-homoserine-lactone synthase VanM;
DE            Short=AHL synthase VanM;
DE            EC=2.3.1.184;
GN   Name=vanM;
OS   Vibrio anguillarum (Listonella anguillarum).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=55601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN HOMOSERINE LACTONE
RP   SYNTHESIS.
RC   STRAIN=NB10 / Serotype O1;
RX   PubMed=11371516; DOI=10.1128/jb.183.12.3537-3547.2001;
RA   Milton D.L., Chalker V.J., Kirke D., Hardman A., Camara M., Williams P.;
RT   "The LuxM homologue VanM from Vibrio anguillarum directs the synthesis of
RT   N-(3-hydroxyhexanoyl)homoserine lactone and N-hexanoylhomoserine lactone.";
RL   J. Bacteriol. 183:3537-3547(2001).
CC   -!- FUNCTION: Required for the synthesis of N-(3-hydroxyhexanoyl)homoserine
CC       lactone (3-hydroxy-C6-HSL) and N-hexanoylhomoserine lactone (C6-HSL).
CC       {ECO:0000269|PubMed:11371516}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-
CC         homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine;
CC         Xref=Rhea:RHEA:10096, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:55474,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651;
CC         EC=2.3.1.184;
CC   -!- SIMILARITY: Belongs to the LuxM / VanM family. {ECO:0000305}.
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DR   EMBL; AF288163; AAG01003.1; -; Genomic_DNA.
DR   RefSeq; WP_013868032.1; NZ_VSLF01000019.1.
DR   AlphaFoldDB; Q9FDA3; -.
DR   STRING; 55601.VANGNB10_cII0822; -.
DR   OMA; FWCECEI; -.
DR   OrthoDB; 1074258at2; -.
DR   GO; GO:0061579; F:N-acyl homoserine lactone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   InterPro; IPR035304; AHL_synthase.
DR   Pfam; PF17327; AHL_synthase; 1.
PE   1: Evidence at protein level;
KW   Autoinducer synthesis; Quorum sensing; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..400
FT                   /note="Acyl-homoserine-lactone synthase VanM"
FT                   /id="PRO_0000379486"
SQ   SEQUENCE   400 AA;  47297 MW;  19B07C14C9B0490E CRC64;
     MKIISSLGSR LTNSLPIEKK QRALVEFVIN TYQPQQRADL FRALTEHRKN QLLNLFPEHH
     NKSFSILFEL MDYRELIRRY PNTFGEEIAH LEQAVSECYS HWLDFWCECE IAAIKTLFPI
     EADAPHRIEL PLKDCAYRGF LIDQIEDSEL WVTTPSHPQK MPIKDAITLS NLELFIKGEK
     WYEMLPLLSL SQKGKHFVLL KHPNNEASPT LVASMLVQDW SVNQTWLSYA QQFSNEQWQF
     CLPDHSYDVL MELQLFKPAL SKCDSLPEFD HQFRRQLTGT QAVCEVLRLT VSGNAQQKLY
     FLYLAQKKLI QILNQMGYKI GFTIIEQPFI LNFYQTIEPK SYFRSGYNDL NNNGKQSYRG
     FWMIERMDKV FSDTNFRDYR HAVSQRRKYD LTKRKEKEYA