ID   VANR_VIBAN              Reviewed;         240 AA.
AC   P74946;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Transcriptional activator protein VanR;
GN   Name=vanR;
OS   Vibrio anguillarum (Listonella anguillarum).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=55601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NB10 / Serotype O1;
RX   PubMed=9139920; DOI=10.1128/jb.179.9.3004-3012.1997;
RA   Milton D.L., Hardman A., Camara M., Chhabra S.R., Bycroft B.W.,
RA   Stewart G.S.A.B., Williams P.;
RT   "Quorum sensing in Vibrio anguillarum: characterization of the vanI/vanR
RT   locus and identification of the autoinducer N-(3-oxodecanoyl)-L-homoserine
RT   lactone.";
RL   J. Bacteriol. 179:3004-3012(1997).
CC   -!- FUNCTION: Probable transcriptional activator. Binds to autoinducer
CC       molecule ODHL.
CC   -!- SIMILARITY: Belongs to the autoinducer-regulated transcriptional
CC       regulatory protein family. {ECO:0000305}.
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DR   EMBL; U69677; AAC45213.1; -; Genomic_DNA.
DR   RefSeq; WP_013868064.1; NZ_VSLF01000016.1.
DR   AlphaFoldDB; P74946; -.
DR   SMR; P74946; -.
DR   STRING; 55601.VANGNB10_cII0861; -.
DR   OMA; RESLQWV; -.
DR   OrthoDB; 1687028at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:1901336; P:lactone biosynthetic process; IMP:CACAO.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.80; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR   InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03472; Autoind_bind; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF75516; SSF75516; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Quorum sensing; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..240
FT                   /note="Transcriptional activator protein VanR"
FT                   /id="PRO_0000184195"
FT   DOMAIN          169..234
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        193..212
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   240 AA;  27253 MW;  BF9E0C40564C6663 CRC64;
     MYKILRLIQE NQQITSHDDL ENVLNGLNNL IGHEFFLFGL SFQPTLKTSE TLVTDNYPNS
     WRQQYDESGF MHIDPIVKYS ITNFLPIRWD DAKRVNNDGR VIFEEARCNG LKAGFSIPIH
     GLRGEFGMIS FATSDTKSYD LNQQSIHTSQ LIVPLLAHNI GNITRYHKDA KPRAVLTARE
     VQCLAWAAEG KSAWEIATII NTSERTVKFH FSNACKKLGA TNRYQAITKA ILGGYINPYL