ID   VANW_ENTFA              Reviewed;         275 AA.
AC   Q47747;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Vancomycin B-type resistance protein VanW;
GN   Name=vanW; OrderedLocusNames=EF_2296;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=8631706; DOI=10.1128/jb.178.5.1302-1309.1996;
RA   Evers S., Courvalin P.;
RT   "Regulation of VanB-type vancomycin resistance gene expression by the
RT   VanS(B)-VanR(B) two-component regulatory system in Enterococcus faecalis
RT   V583.";
RL   J. Bacteriol. 178:1302-1309(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- INDUCTION: By vancomycin, mediated by VanS/VanR.
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DR   EMBL; U35369; AAB05625.1; -; Genomic_DNA.
DR   EMBL; AE016830; AAO82023.1; -; Genomic_DNA.
DR   RefSeq; NP_815953.1; NC_004668.1.
DR   RefSeq; WP_002368694.1; NZ_KE136528.1.
DR   AlphaFoldDB; Q47747; -.
DR   STRING; 226185.EF_2296; -.
DR   EnsemblBacteria; AAO82023; AAO82023; EF_2296.
DR   KEGG; efa:EF2296; -.
DR   PATRIC; fig|226185.45.peg.1236; -.
DR   eggNOG; COG2720; Bacteria.
DR   HOGENOM; CLU_072547_1_0_9; -.
DR   OMA; PLTYKIS; -.
DR   Proteomes; UP000001415; Chromosome.
DR   InterPro; IPR007391; Vancomycin_resist_VanW.
DR   Pfam; PF04294; VanW; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..275
FT                   /note="Vancomycin B-type resistance protein VanW"
FT                   /id="PRO_0000065761"
SQ   SEQUENCE   275 AA;  31405 MW;  C17CFA9657028124 CRC64;
     MNRKRLTQRF PFLLPMRQAQ RKICFYAGMR FDGCCYAQTI GEKTLPYLLF ETDCALYNHN
     TGFDMIYQEN KVFNLKLAAK TLNGLLIKPG ETFSFWRLVR HADKDTPYKD GLTVANGKLT
     TMSGGGMCQM SNLLFWVFLH TPLTIIQRSG HVVKEFPEPN SDEIKGVDAT ISEGWIDLKV
     RNDTDCTYQI WVTLDDEKII GQVFADKQPQ ALYKIANGSI QYVRESGGIY EYAKVERMQV
     ALGTGEIIDC KLLYTNKCKI CYPLPESVDI QEANQ