ID   VANZ_ENTFC              Reviewed;         161 AA.
AC   Q06242;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Protein VanZ;
GN   Name=vanZ;
OS   Enterococcus faecium (Streptococcus faecium).
OG   Plasmid pIP816.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1352;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BM4147; TRANSPOSON=Tn1546;
RX   PubMed=8380148; DOI=10.1128/jb.175.1.117-127.1993;
RA   Arthur M., Molinas C., Depardieu F., Courvalin P.;
RT   "Characterization of Tn1546, a Tn3-related transposon conferring
RT   glycopeptide resistance by synthesis of depsipeptide peptidoglycan
RT   precursors in Enterococcus faecium BM4147.";
RL   J. Bacteriol. 175:117-127(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BM4147; TRANSPOSON=Tn1546;
RX   PubMed=7867956; DOI=10.1016/0378-1119(94)00851-i;
RA   Arthur M., Depardieu F., Molinas C., Reynolds P., Courvalin P.;
RT   "The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers
RT   resistance to teicoplanin.";
RL   Gene 154:87-92(1995).
CC   -!- FUNCTION: Unknown. Confers low-level resistance to teicoplanin.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; M97297; AAA65959.1; -; Genomic_DNA.
DR   RefSeq; WP_000516404.1; NZ_WSZC01000082.1.
DR   RefSeq; YP_001019032.1; NC_008821.1.
DR   RefSeq; YP_001974793.1; NC_010980.1.
DR   RefSeq; YP_002128402.1; NC_011140.1.
DR   RefSeq; YP_004172612.1; NC_014959.1.
DR   RefSeq; YP_006937545.1; NC_013317.1.
DR   RefSeq; YP_007908265.1; NC_021170.1.
DR   RefSeq; YP_976074.1; NC_008768.1.
DR   AlphaFoldDB; Q06242; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR006976; VanZ-like.
DR   Pfam; PF04892; VanZ; 1.
PE   4: Predicted;
KW   Antibiotic resistance; Cell wall biogenesis/degradation; Plasmid; Secreted.
FT   CHAIN           1..161
FT                   /note="Protein VanZ"
FT                   /id="PRO_0000065762"
SQ   SEQUENCE   161 AA;  18427 MW;  9B255B06F07551DF CRC64;
     MGKILSRGLL ALYLVTLIWL VLFKLQYNIL SVFNYHQRSL NLTPFTATGN FREMIDNVII
     FIPFGLLLNV NFKEIGFLPK FAFVLVLSLT FEIIQFIFAI GATDITDVIT NTVGGFLGLK
     LYGLSNKHMN QKKLDRVIIF VGILLLVLLL VYRTHLRINY V