ID   VAP1_STRPU              Reviewed;         433 AA.
AC   Q06155;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Vesicle-associated protein;
DE   AltName: Full=VAP-1;
DE   Flags: Fragment;
GN   Name=VAP-1;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=1478972; DOI=10.1242/jcs.103.3.797;
RA   Barton N.R., Bonder E.M., Fishkind D.J., Warren R.H., Pratt M.M.;
RT   "A novel vesicle-associated protein (VAP-1) in sea urchin eggs containing
RT   multiple RNA-binding consensus sequences.";
RL   J. Cell Sci. 103:797-809(1992).
CC   -!- FUNCTION: May function as a multidomain RNA-binding protein. May play a
CC       role in nuclear RNA processing and in early development.
CC   -!- SUBCELLULAR LOCATION: Microsome membrane; Peripheral membrane protein.
CC       Nucleus {ECO:0000305}. Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Note=Initially a peripheral membrane protein
CC       associated with the microsomal membrane fractions. May be targeted to
CC       the nucleus later in development.
CC   -!- TISSUE SPECIFICITY: Egg cortex.
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DR   EMBL; X69993; CAA49608.1; -; mRNA.
DR   PIR; T01405; T01405.
DR   AlphaFoldDB; Q06155; -.
DR   STRING; 7668.SPU_018932-tr; -.
DR   eggNOG; ENOG502QTQ3; Eukaryota.
DR   HOGENOM; CLU_224310_0_0_1; -.
DR   InParanoid; Q06155; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0043484; P:regulation of RNA splicing; IBA:GO_Central.
PE   2: Evidence at transcript level;
KW   Developmental protein; Endoplasmic reticulum; Membrane; Microsome; Nucleus;
KW   Reference proteome; Repeat; RNA-binding.
FT   CHAIN           <1..>433
FT                   /note="Vesicle-associated protein"
FT                   /id="PRO_0000065765"
FT   REPEAT          112..122
FT                   /note="1"
FT   REPEAT          219..229
FT                   /note="2"
FT   REPEAT          340..350
FT                   /note="3"
FT   REGION          112..350
FT                   /note="3 X 11 AA repeats of G-G-G-I-G-G-G-L-G-G-G"
FT   REGION          366..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          411..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           266..274
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        412..426
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         433
SQ   SEQUENCE   433 AA;  42126 MW;  9A72FEA27DFD22CB CRC64;
     TDIGGGLDVG GGLRGGLDID AKGPDVDIKG PKVGGDISGP DLDVSGPDLD IDGGGKKGKG
     GFGFGLKMPK FGFGGHGKGD IDVDADVDIE RPDLDVSGDA DLPSGGVGLD VGGGIGGGLG
     GGLDIDANGP DVDIKGPKVG GDISGPDLDV SGPDLDIDVD GKKKGKGGFG FGMKMPKFGF
     GGHGKGDIDV DADVDIERPD LDVSGDADLP SGGVGLDVGG GIGGGLGGGL DIDANGPDVD
     IKGPKVGGDI SGPDLDVSGP DLDIDVDGKK KGKGGFGFGL KIPKFMDPTF GFGGHGKGDI
     DVDADGGVVI PEGDIKVKTG KPDIGGDVDL PSGGVDLDVG GGIGGGLGGG LDIDAKGPDV
     DIKGPRVGGD ISGPDLDVSG PDLDIDGDGK KKGKGGFGFG LKMPKFGFGG HGKGDIDVDA
     DVDIERPDLN VSG