ID   VAPB1_HAEIN             Reviewed;          78 AA.
AC   Q57534;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Antitoxin VapB1;
GN   Name=vapB1; OrderedLocusNames=HI_0321;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the effect of toxin VapC1 (By similarity).
CC       {ECO:0000250|UniProtKB:Q4QNL8}.
CC   -!- SIMILARITY: Belongs to the VapB family. {ECO:0000305}.
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DR   EMBL; L42023; AAC21984.1; -; Genomic_DNA.
DR   PIR; F64061; F64061.
DR   RefSeq; NP_438486.1; NC_000907.1.
DR   RefSeq; WP_005649046.1; NC_000907.1.
DR   PDB; 6NKL; X-ray; 2.20 A; C/D=1-78.
DR   PDBsum; 6NKL; -.
DR   AlphaFoldDB; Q57534; -.
DR   SMR; Q57534; -.
DR   STRING; 71421.HI_0321; -.
DR   EnsemblBacteria; AAC21984; AAC21984; HI_0321.
DR   KEGG; hin:HI_0321; -.
DR   PATRIC; fig|71421.8.peg.338; -.
DR   eggNOG; COG4456; Bacteria.
DR   HOGENOM; CLU_162018_2_1_6; -.
DR   OMA; HITRVFQ; -.
DR   BioCyc; HINF71421:G1GJ1-337-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR007159; SpoVT-AbrB_dom.
DR   InterPro; IPR037914; SpoVT-AbrB_sf.
DR   Pfam; PF04014; MazE_antitoxin; 1.
DR   SMART; SM00966; SpoVT_AbrB; 1.
DR   SUPFAM; SSF89447; SSF89447; 1.
DR   PROSITE; PS51740; SPOVT_ABRB; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..78
FT                   /note="Antitoxin VapB1"
FT                   /id="PRO_0000077909"
FT   DOMAIN          3..44
FT                   /note="SpoVT-AbrB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01076"
FT   STRAND          1..8
FT                   /evidence="ECO:0007829|PDB:6NKL"
FT   STRAND          11..16
FT                   /evidence="ECO:0007829|PDB:6NKL"
FT   HELIX           18..20
FT                   /evidence="ECO:0007829|PDB:6NKL"
FT   STRAND          23..31
FT                   /evidence="ECO:0007829|PDB:6NKL"
FT   STRAND          37..41
FT                   /evidence="ECO:0007829|PDB:6NKL"
FT   HELIX           44..51
FT                   /evidence="ECO:0007829|PDB:6NKL"
FT   TURN            52..55
FT                   /evidence="ECO:0007829|PDB:6NKL"
FT   HELIX           58..65
FT                   /evidence="ECO:0007829|PDB:6NKL"
SQ   SEQUENCE   78 AA;  9037 MW;  468D048ED7C5C720 CRC64;
     MLTKVFQSGN SQAVRIPMDF RFDVDTVEIF RKENGDVVLR PVSKKTDDFL ALFEGFDETF
     IQALEARDDL PPQERENL