ID   VAPB1_MYCTU             Reviewed;          79 AA.
AC   P0CW29; L0T5E8;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Putative antitoxin VapB1;
GN   Name=vapB1; OrderedLocusNames=Rv0064A;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION, AND POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Antitoxin component of a possible type II toxin-antitoxin
CC       (TA) system. The cognate toxin is VapC1. {ECO:0000305|PubMed:15718296}.
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DR   EMBL; AL123456; CCP42787.1; -; Genomic_DNA.
DR   RefSeq; WP_003400577.1; NZ_NVQJ01000005.1.
DR   RefSeq; YP_007408701.1; NC_000962.3.
DR   AlphaFoldDB; P0CW29; -.
DR   SMR; P0CW29; -.
DR   STRING; 83332.Rv0064A; -.
DR   GeneID; 14515844; -.
DR   KEGG; mtu:Rv0064A; -.
DR   TubercuList; Rv0064A; -.
DR   eggNOG; ENOG502ZQU1; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   4: Predicted;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..79
FT                   /note="Putative antitoxin VapB1"
FT                   /id="PRO_0000408051"
SQ   SEQUENCE   79 AA;  8718 MW;  36DFEF1E8B8E9E24 CRC64;
     MATIQVRDLP EDVAETYRRR ATAAGQSLQT YMRTKLIEGV RGRDKAEAIE ILEQALASTA
     SPGISRETIE ASRRELRGG