ID   VAPB2_HAEIN             Reviewed;          77 AA.
AC   Q57120; O05037;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Antitoxin VapB2;
GN   Name=vapB2; OrderedLocusNames=HI_0948;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the effect of toxin VapC2 (By similarity).
CC       {ECO:0000250|UniProtKB:Q4QLV9}.
CC   -!- SIMILARITY: Belongs to the VapB family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22609.1; -; Genomic_DNA.
DR   PIR; C64162; C64162.
DR   RefSeq; NP_439109.1; NC_000907.1.
DR   RefSeq; WP_005648011.1; NC_000907.1.
DR   AlphaFoldDB; Q57120; -.
DR   SMR; Q57120; -.
DR   STRING; 71421.HI_0948; -.
DR   EnsemblBacteria; AAC22609; AAC22609; HI_0948.
DR   KEGG; hin:HI_0948; -.
DR   PATRIC; fig|71421.8.peg.990; -.
DR   eggNOG; COG4456; Bacteria.
DR   HOGENOM; CLU_162018_3_1_6; -.
DR   OMA; VFTNNRS; -.
DR   PhylomeDB; Q57120; -.
DR   BioCyc; HINF71421:G1GJ1-989-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR007159; SpoVT-AbrB_dom.
DR   InterPro; IPR037914; SpoVT-AbrB_sf.
DR   Pfam; PF04014; MazE_antitoxin; 1.
DR   SUPFAM; SSF89447; SSF89447; 1.
DR   PROSITE; PS51740; SPOVT_ABRB; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..77
FT                   /note="Antitoxin VapB2"
FT                   /id="PRO_0000219874"
FT   DOMAIN          4..46
FT                   /note="SpoVT-AbrB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01076"
SQ   SEQUENCE   77 AA;  8881 MW;  50489BBE4678CD6D CRC64;
     MIEASVFMTN RSQAVRLPAE VRFSEEIKKL SVRVSGSDRI LSPLNQSWDS FFLNDQAVSD
     DFMNEREIAF QPEREAL