ID   VAPB2_METJA             Reviewed;          64 AA.
AC   Q58385;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Putative antitoxin MJ0975;
GN   Name=vapB2; OrderedLocusNames=MJ0975;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Possibly the antitoxin component of a type II toxin-antitoxin
CC       (TA) system. Its cognate toxin is VapC2 (Potential). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0165 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB98981.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; L77117; AAB98981.1; ALT_INIT; Genomic_DNA.
DR   PIR; G64421; G64421.
DR   RefSeq; WP_064496686.1; NC_000909.1.
DR   AlphaFoldDB; Q58385; -.
DR   STRING; 243232.MJ_0975; -.
DR   EnsemblBacteria; AAB98981; AAB98981; MJ_0975.
DR   GeneID; 1451873; -.
DR   KEGG; mja:MJ_0975; -.
DR   eggNOG; arCOG08303; Archaea.
DR   HOGENOM; CLU_200885_3_1_2; -.
DR   InParanoid; Q58385; -.
DR   OMA; CEVEIKI; -.
DR   Proteomes; UP000000805; Chromosome.
DR   Gene3D; 4.10.1150.10; -; 1.
DR   InterPro; IPR008203; AF2212-like.
DR   InterPro; IPR024069; AF2212-like_dom_sf.
DR   Pfam; PF01954; DUF104; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..64
FT                   /note="Putative antitoxin MJ0975"
FT                   /id="PRO_0000156858"
SQ   SEQUENCE   64 AA;  7214 MW;  C10D5F4CA7C7094F CRC64;
     MEIVVDAIYE KGVLKLKKSI NLPEGCEVEI KIIPKKISEK TFGILKLSDK EIKEILEEIE
     NGGE