ID   VAPB2_PYRAB             Reviewed;          76 AA.
AC   Q9V1M3; G8ZGA3;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Putative antitoxin VapB2 {ECO:0000255|HAMAP-Rule:MF_00794};
GN   Name=vapB2; OrderedLocusNames=PYRAB04040; ORFNames=PAB3103;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
RN   [3]
RP   POSSIBLE FUNCTION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Possibly the antitoxin component of a type II toxin-antitoxin
CC       (TA) system. Its cognate toxin is VapC2 (Potential).
CC       {ECO:0000255|HAMAP-Rule:MF_00794}.
CC   -!- SIMILARITY: Belongs to the UPF0330 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00794}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB49326.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AJ248284; CAB49326.1; ALT_INIT; Genomic_DNA.
DR   EMBL; HE613800; CCE69782.1; -; Genomic_DNA.
DR   PIR; G75155; G75155.
DR   RefSeq; WP_048146550.1; NC_000868.1.
DR   AlphaFoldDB; Q9V1M3; -.
DR   EnsemblBacteria; CAB49326; CAB49326; PAB3103.
DR   GeneID; 1495295; -.
DR   KEGG; pab:PAB3103; -.
DR   PATRIC; fig|272844.11.peg.423; -.
DR   eggNOG; arCOG02681; Archaea.
DR   HOGENOM; CLU_170073_3_0_2; -.
DR   OrthoDB; 124152at2157; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   HAMAP; MF_00794; UPF0330; 1.
DR   InterPro; IPR003847; Put_antitoxin.
DR   Pfam; PF02697; VAPB_antitox; 1.
PE   3: Inferred from homology;
KW   Toxin-antitoxin system.
FT   CHAIN           1..76
FT                   /note="Putative antitoxin VapB2"
FT                   /id="PRO_0000157110"
SQ   SEQUENCE   76 AA;  8845 MW;  8887882CB726366D CRC64;
     MSKTITIADD VYYELVKMKG NKSFSELLRE LIGKKKKGNL DILMIAFGTM SEEEVKEFKK
     KIKEVEEWIN SWTPVS