ID   VAPB3_METAC             Reviewed;          77 AA.
AC   Q8TQM6;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Putative antitoxin VapB3 {ECO:0000255|HAMAP-Rule:MF_00794};
GN   Name=vapB3; OrderedLocusNames=MA_1514;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Possibly the antitoxin component of a type II toxin-antitoxin
CC       (TA) system. Its cognate toxin is VapC3 (Potential).
CC       {ECO:0000255|HAMAP-Rule:MF_00794}.
CC   -!- SIMILARITY: Belongs to the UPF0330 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00794}.
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DR   EMBL; AE010299; AAM04928.1; -; Genomic_DNA.
DR   RefSeq; WP_011021528.1; NC_003552.1.
DR   AlphaFoldDB; Q8TQM6; -.
DR   EnsemblBacteria; AAM04928; AAM04928; MA_1514.
DR   GeneID; 1473402; -.
DR   KEGG; mac:MA_1514; -.
DR   HOGENOM; CLU_170073_1_0_2; -.
DR   OMA; MNTPRSQ; -.
DR   OrthoDB; 121782at2157; -.
DR   Proteomes; UP000002487; Chromosome.
DR   HAMAP; MF_00794; UPF0330; 1.
DR   InterPro; IPR003847; Put_antitoxin.
DR   Pfam; PF02697; VAPB_antitox; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..77
FT                   /note="Putative antitoxin VapB3"
FT                   /id="PRO_0000157107"
SQ   SEQUENCE   77 AA;  8790 MW;  BEDCC6289456FDD1 CRC64;
     MPTRTISISE EAYEKLKSLK SSEKDSFSDV ILRYYPKKRK LSEVLAEIGP NPELADAIEK
     VSGEMRAEKM REIDPES