ID   VAPB3_PYRAE             Reviewed;          77 AA.
AC   Q8ZZP2;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Putative antitoxin VapB3;
GN   Name=vAPb3; OrderedLocusNames=PAE0152;
OS   Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS   104966 / NBRC 100827 / IM2).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=178306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX   PubMed=11792869; DOI=10.1073/pnas.241636498;
RA   Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA   Miller J.H.;
RT   "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT   aerophilum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   SUBUNIT.
RC   STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX   PubMed=18398909; DOI=10.1002/prot.22048;
RA   Bunker R.D., McKenzie J.L., Baker E.N., Arcus V.L.;
RT   "Crystal structure of PAE0151 from Pyrobaculum aerophilum, a PIN-domain
RT   (VapC) protein from a toxin-antitoxin operon.";
RL   Proteins 72:510-518(2008).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       {ECO:0000305}.
CC   -!- SUBUNIT: Forms a complex with putative toxin VapC3, possibly VapB(2)-
CC       VapC(2). {ECO:0000269|PubMed:18398909}.
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DR   EMBL; AE009441; AAL62597.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8ZZP2; -.
DR   SMR; Q8ZZP2; -.
DR   STRING; 178306.PAE0152; -.
DR   EnsemblBacteria; AAL62597; AAL62597; PAE0152.
DR   KEGG; pai:PAE0152; -.
DR   PATRIC; fig|178306.9.peg.109; -.
DR   eggNOG; arCOG02218; Archaea.
DR   HOGENOM; CLU_175270_2_0_2; -.
DR   OMA; KSHGYYS; -.
DR   Proteomes; UP000002439; Chromosome.
DR   InterPro; IPR039709; VapB3-like.
DR   PANTHER; PTHR42244; PTHR42244; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..77
FT                   /note="Putative antitoxin VapB3"
FT                   /id="PRO_0000408090"
FT   COILED          10..60
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   77 AA;  9120 MW;  1F211CD869CA2B1A CRC64;
     MSEVISIRVR RGLKKELEEL GINYAEAVRK FLEELVARER RRRALERARA LREELRKKGA
     FPPSAELIRE DRDEASR