ID   VAPB3_PYRFU             Reviewed;          46 AA.
AC   Q8U394;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Putative antitoxin VapB3;
GN   Name=vapB3; OrderedLocusNames=PF0576;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Possibly the antitoxin component of a type II toxin-antitoxin
CC       (TA) system. Its cognate toxin is VapC3 (Potential). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0165 family. {ECO:0000305}.
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DR   EMBL; AE009950; AAL80700.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8U394; -.
DR   SMR; Q8U394; -.
DR   STRING; 186497.PF0576; -.
DR   EnsemblBacteria; AAL80700; AAL80700; PF0576.
DR   KEGG; pfu:PF0576; -.
DR   PATRIC; fig|186497.12.peg.604; -.
DR   eggNOG; arCOG07152; Archaea.
DR   HOGENOM; CLU_3178717_0_0_2; -.
DR   Proteomes; UP000001013; Chromosome.
DR   Gene3D; 4.10.1150.10; -; 1.
DR   InterPro; IPR008203; AF2212-like.
DR   InterPro; IPR024069; AF2212-like_dom_sf.
DR   Pfam; PF01954; DUF104; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..46
FT                   /note="Putative antitoxin VapB3"
FT                   /id="PRO_0000156862"
SQ   SEQUENCE   46 AA;  5442 MW;  517FA67E13A01A6B CRC64;
     MQIVEAIYED GVLKLLKNLK LKEHSKVIIK VIDEEEIEKI LDSRDY