ID   VAPB4_ARCFU             Reviewed;          64 AA.
AC   O29931;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Putative antitoxin VapB4;
GN   Name=vapB4; OrderedLocusNames=AF_0314;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
RN   [2]
RP   IDENTIFICATION, AND POSSIBLE FUNCTION.
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Possibly the antitoxin component of a type II toxin-antitoxin
CC       (TA) system. Its cognate toxin is VapC4 (Potential). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0165 family. {ECO:0000305}.
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DR   EMBL; AE000782; AAB90923.1; -; Genomic_DNA.
DR   PIR; B69289; B69289.
DR   RefSeq; WP_010877821.1; NC_000917.1.
DR   AlphaFoldDB; O29931; -.
DR   SMR; O29931; -.
DR   STRING; 224325.AF_0314; -.
DR   EnsemblBacteria; AAB90923; AAB90923; AF_0314.
DR   GeneID; 24793851; -.
DR   KEGG; afu:AF_0314; -.
DR   eggNOG; arCOG03880; Archaea.
DR   HOGENOM; CLU_200885_3_1_2; -.
DR   OMA; CEVEIKI; -.
DR   OrthoDB; 126557at2157; -.
DR   PhylomeDB; O29931; -.
DR   Proteomes; UP000002199; Chromosome.
DR   Gene3D; 4.10.1150.10; -; 1.
DR   InterPro; IPR008203; AF2212-like.
DR   InterPro; IPR024069; AF2212-like_dom_sf.
DR   Pfam; PF01954; DUF104; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..64
FT                   /note="Putative antitoxin VapB4"
FT                   /id="PRO_0000156846"
SQ   SEQUENCE   64 AA;  7255 MW;  4405986D9618D4A6 CRC64;
     MPKIIEAIYE NGVFKPLQKV DLKEGEKAKI VLESISDKTF GILKASETEI KKVLEEIDDF
     WGVC