ID   VAPB4_PYRFU             Reviewed;          78 AA.
AC   Q8U2Q8;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Putative antitoxin VapB4 {ECO:0000255|HAMAP-Rule:MF_00794};
GN   Name=vapB4; OrderedLocusNames=PF0774;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Possibly the antitoxin component of a type II toxin-antitoxin
CC       (TA) system. Its cognate toxin is VapC4 (Potential).
CC       {ECO:0000255|HAMAP-Rule:MF_00794}.
CC   -!- SIMILARITY: Belongs to the UPF0330 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00794}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL80898.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE009950; AAL80898.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_014835226.1; NZ_CP023154.1.
DR   AlphaFoldDB; Q8U2Q8; -.
DR   SMR; Q8U2Q8; -.
DR   STRING; 186497.PF0774; -.
DR   EnsemblBacteria; AAL80898; AAL80898; PF0774.
DR   GeneID; 41712573; -.
DR   KEGG; pfu:PF0774; -.
DR   PATRIC; fig|186497.12.peg.814; -.
DR   eggNOG; arCOG02681; Archaea.
DR   HOGENOM; CLU_170073_3_0_2; -.
DR   Proteomes; UP000001013; Chromosome.
DR   HAMAP; MF_00794; UPF0330; 1.
DR   InterPro; IPR003847; Put_antitoxin.
DR   Pfam; PF02697; VAPB_antitox; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..78
FT                   /note="Putative antitoxin VapB4"
FT                   /id="PRO_0000157111"
SQ   SEQUENCE   78 AA;  9373 MW;  132502F6BD9AC213 CRC64;
     MVKTITVSDD VYNELLRIKG KKSFSELLRE LLREKKGNSV ALKHIYGILN GEEYRETRKR
     LKELEKEFEK WKQFLTQV