VAPB7_MYCTU
ID VAPB7_MYCTU Reviewed; 84 AA.
AC O06777; L0T4C9;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 4.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Putative antitoxin VapB7;
GN Name=vapB7; OrderedLocusNames=Rv0662c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP POSSIBLE FUNCTION.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=15718296; DOI=10.1093/nar/gki201;
RA Pandey D.P., Gerdes K.;
RT "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT host-associated prokaryotes.";
RL Nucleic Acids Res. 33:966-976(2005).
CC -!- FUNCTION: Antitoxin component of a possible type II toxin-antitoxin
CC (TA) system. The cognate toxin is VapC7. {ECO:0000305|PubMed:15718296}.
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DR EMBL; AL123456; CCP43405.1; -; Genomic_DNA.
DR PIR; A70535; A70535.
DR RefSeq; NP_215176.2; NC_000962.3.
DR RefSeq; WP_003911263.1; NZ_NVQJ01000007.1.
DR AlphaFoldDB; O06777; -.
DR SMR; O06777; -.
DR STRING; 83332.Rv0662c; -.
DR PaxDb; O06777; -.
DR DNASU; 888117; -.
DR GeneID; 888117; -.
DR KEGG; mtu:Rv0662c; -.
DR PATRIC; fig|83332.111.peg.735; -.
DR TubercuList; Rv0662c; -.
DR eggNOG; ENOG5033JAC; Bacteria.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
PE 4: Predicted;
KW Reference proteome; Toxin-antitoxin system.
FT CHAIN 1..84
FT /note="Putative antitoxin VapB7"
FT /id="PRO_0000408055"
SQ SEQUENCE 84 AA; 9451 MW; 48CBBC9689EB378C CRC64;
MSMRLAHRLQ ILLDDECHRR ITAVARERGV PVATVVREAI DRGLVSPAGR RKSAGRRLLD
AADMSVPEPR ELKQELEALR ARRG