ID   VAPB8_MYCTU             Reviewed;          90 AA.
AC   O06775; L0T7D0;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Putative antitoxin VapB8;
GN   Name=vapB8; OrderedLocusNames=Rv0664;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Antitoxin component of a possible type II toxin-antitoxin
CC       (TA) system. The cognate toxin is VapC8. {ECO:0000305|PubMed:15718296}.
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DR   EMBL; AL123456; CCP43407.1; -; Genomic_DNA.
DR   PIR; C70535; C70535.
DR   RefSeq; NP_215178.1; NC_000962.3.
DR   RefSeq; WP_003900200.1; NC_000962.3.
DR   AlphaFoldDB; O06775; -.
DR   STRING; 83332.Rv0664; -.
DR   PaxDb; O06775; -.
DR   DNASU; 888146; -.
DR   GeneID; 888146; -.
DR   KEGG; mtu:Rv0664; -.
DR   TubercuList; Rv0664; -.
DR   OMA; WGAGRRY; -.
DR   Proteomes; UP000001584; Chromosome.
PE   4: Predicted;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..90
FT                   /note="Putative antitoxin VapB8"
FT                   /id="PRO_0000408057"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   90 AA;  9250 MW;  6543B6DA6F5F8ECC CRC64;
     MEKSRCHAVA HGGGCAGSAK SHKSGGRCGQ GRGAGDSHGT RGAGRRYRAA SAPHPLAVGA
     HLRDELAKRS ADPRLTDELN DLAGHTLDDL