VAPB9_MYCTU
ID VAPB9_MYCTU Reviewed; 73 AA.
AC P9WJ55; F2GHW7; P0CW30; Q8VKA9;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 29.
DE RecName: Full=Putative antitoxin VapB9;
GN Name=vapB9; OrderedLocusNames=Rv0959A;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION, AND POSSIBLE FUNCTION.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=15718296; DOI=10.1093/nar/gki201;
RA Pandey D.P., Gerdes K.;
RT "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT host-associated prokaryotes.";
RL Nucleic Acids Res. 33:966-976(2005).
CC -!- FUNCTION: Antitoxin component of a possible type II toxin-antitoxin
CC (TA) system. The cognate toxin is VapC9. {ECO:0000305|PubMed:15718296}.
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DR EMBL; AL123456; CCP43708.1; -; Genomic_DNA.
DR RefSeq; WP_003404898.1; NZ_NVQJ01000001.1.
DR RefSeq; YP_007409620.1; NC_000962.3.
DR AlphaFoldDB; P9WJ55; -.
DR SMR; P9WJ55; -.
DR STRING; 83332.Rv0959A; -.
DR GeneID; 14515852; -.
DR KEGG; mtu:Rv0959A; -.
DR TubercuList; Rv0959A; -.
DR eggNOG; ENOG50330FN; Bacteria.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR010985; Ribbon_hlx_hlx.
DR SUPFAM; SSF47598; SSF47598; 1.
PE 4: Predicted;
KW Reference proteome; Toxin-antitoxin system.
FT CHAIN 1..73
FT /note="Putative antitoxin VapB9"
FT /id="PRO_0000408058"
SQ SEQUENCE 73 AA; 7918 MW; 9055EA99193F5435 CRC64;
MKTLYLRNVP DDVVERLERL AELAKTSVSA VAVRELTEAS RRADNPALLG DLPDIGIDTT
ELIGGIDAER AGR