VAPB_BOVIN
ID VAPB_BOVIN Reviewed; 243 AA.
AC A2VDZ9;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Vesicle-associated membrane protein-associated protein B;
DE Short=VAMP-B;
DE Short=VAMP-associated protein B;
DE Short=VAP-B;
GN Name=VAPB;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Basal ganglia;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in the endoplasmic reticulum unfolded protein
CC response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular
CC calcium homeostasis regulation. {ECO:0000250|UniProtKB:O95292}.
CC -!- SUBUNIT: Homodimer, and heterodimer with VAPA. Interacts with RMDN3,
CC VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27. Interacts
CC with KIF5A in a ZFYVE27-dependent manner. Interacts with STARD3 (via
CC FFAT motif) (By similarity). Interacts with STARD3NL (via FFAT motif)
CC (By similarity). Interacts with CERT1 (By similarity). Interacts with
CC PLEKHA3 and SACM1L to form a ternary complex (By similarity). Interacts
CC with VPS13A (via FFAT motif) (By similarity).
CC {ECO:0000250|UniProtKB:O95292}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:O95292}; Single-pass type IV membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17)
CC family. {ECO:0000305}.
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DR EMBL; BC133497; AAI33498.1; -; mRNA.
DR RefSeq; NP_001075892.1; NM_001082423.1.
DR AlphaFoldDB; A2VDZ9; -.
DR BMRB; A2VDZ9; -.
DR SMR; A2VDZ9; -.
DR STRING; 9913.ENSBTAP00000023164; -.
DR PaxDb; A2VDZ9; -.
DR PeptideAtlas; A2VDZ9; -.
DR PRIDE; A2VDZ9; -.
DR Ensembl; ENSBTAT00000023164; ENSBTAP00000023164; ENSBTAG00000017424.
DR GeneID; 326580; -.
DR KEGG; bta:326580; -.
DR CTD; 9217; -.
DR VEuPathDB; HostDB:ENSBTAG00000017424; -.
DR VGNC; VGNC:36764; VAPB.
DR eggNOG; KOG0439; Eukaryota.
DR GeneTree; ENSGT00940000155769; -.
DR HOGENOM; CLU_032848_0_1_1; -.
DR InParanoid; A2VDZ9; -.
DR OMA; TQRMAFK; -.
DR OrthoDB; 1332028at2759; -.
DR TreeFam; TF317024; -.
DR Reactome; R-BTA-1660661; Sphingolipid de novo biosynthesis.
DR Reactome; R-BTA-8980692; RHOA GTPase cycle.
DR Reactome; R-BTA-9013404; RAC2 GTPase cycle.
DR Reactome; R-BTA-9013405; RHOD GTPase cycle.
DR Reactome; R-BTA-9013408; RHOG GTPase cycle.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000017424; Expressed in hypothalamus and 102 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0033149; F:FFAT motif binding; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB.
DR GO; GO:0090158; P:endoplasmic reticulum membrane organization; IBA:GO_Central.
DR GO; GO:0061817; P:endoplasmic reticulum-plasma membrane tethering; IBA:GO_Central.
DR GO; GO:0036498; P:IRE1-mediated unfolded protein response; ISS:UniProtKB.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000535; MSP_dom.
DR InterPro; IPR008962; PapD-like_sf.
DR InterPro; IPR016763; VAP.
DR PANTHER; PTHR10809; PTHR10809; 2.
DR Pfam; PF00635; Motile_Sperm; 1.
DR PIRSF; PIRSF019693; VAMP-associated; 1.
DR SUPFAM; SSF49354; SSF49354; 1.
DR PROSITE; PS50202; MSP; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Coiled coil; Endoplasmic reticulum; Isopeptide bond; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW Ubl conjugation; Unfolded protein response.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O95292"
FT CHAIN 2..243
FT /note="Vesicle-associated membrane protein-associated
FT protein B"
FT /id="PRO_0000308177"
FT TOPO_DOM 2..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT DOMAIN 7..124
FT /note="MSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00132"
FT REGION 186..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 161..196
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:O95292"
FT MOD_RES 146
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O95292"
FT MOD_RES 150
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O95292"
FT MOD_RES 158
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O95292"
FT MOD_RES 159
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O95292"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O95292"
FT MOD_RES 206
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O95292"
FT CROSSLNK 147
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1)"
FT /evidence="ECO:0000250|UniProtKB:O95292"
SQ SEQUENCE 243 AA; 27158 MW; 1ECA446A771C28AA CRC64;
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGI
IDAGASINVS VMLQPFDYDP NEKSKHKFMV QSMFAPTDTS DMEAVWKEAK PEDLMDSKLR
CVFELPAEND KPHDVEINKI IPTTASKTET PTVSKALSSS LDDTEVKKVM EECKRLQSEV
QRLREENKQF KEEDGLRMRK TAQSNSPAPA SAMAGKEEGL STRLLALVVL FFIVGVIIGK
IAL
