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VAPC2_HAEIN
ID   VAPC2_HAEIN             Reviewed;         132 AA.
AC   P71363;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Ribonuclease VapC2 {ECO:0000255|HAMAP-Rule:MF_00265};
DE            Short=RNase VapC2 {ECO:0000255|HAMAP-Rule:MF_00265};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00265};
DE   AltName: Full=Toxin VapC2 {ECO:0000255|HAMAP-Rule:MF_00265};
GN   Name=vapC2 {ECO:0000255|HAMAP-Rule:MF_00265}; OrderedLocusNames=HI_0947;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. An
CC       RNase. Its cognate antitoxin is VapB2 (By similarity).
CC       {ECO:0000250|UniProtKB:Q4QLW0, ECO:0000255|HAMAP-Rule:MF_00265}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00265};
CC   -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_00265}.
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DR   EMBL; L42023; AAC22608.1; -; Genomic_DNA.
DR   PIR; B64104; B64104.
DR   RefSeq; NP_439108.1; NC_000907.1.
DR   RefSeq; WP_005651560.1; NC_000907.1.
DR   AlphaFoldDB; P71363; -.
DR   SMR; P71363; -.
DR   STRING; 71421.HI_0947; -.
DR   EnsemblBacteria; AAC22608; AAC22608; HI_0947.
DR   KEGG; hin:HI_0947; -.
DR   PATRIC; fig|71421.8.peg.989; -.
DR   eggNOG; COG1487; Bacteria.
DR   HOGENOM; CLU_118482_5_3_6; -.
DR   OMA; PYDLQIA; -.
DR   PhylomeDB; P71363; -.
DR   BioCyc; HINF71421:G1GJ1-988-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR   HAMAP; MF_00265; VapC_Nob1; 1.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR022907; VapC_family.
DR   Pfam; PF01850; PIN; 1.
DR   SMART; SM00670; PINc; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Metal-binding; Nuclease; Reference proteome;
KW   Toxin-antitoxin system.
FT   CHAIN           1..132
FT                   /note="Ribonuclease VapC2"
FT                   /id="PRO_0000077981"
FT   DOMAIN          4..130
FT                   /note="PINc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00265"
FT   BINDING         7
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00265"
FT   BINDING         98
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00265"
SQ   SEQUENCE   132 AA;  15148 MW;  A04CBBCCE407B65A CRC64;
     MLKYMLDTNI VIYVIKRRPL EILSRFNQNA GKMCVSSITV AELYYGAEKS EYPERNIAVI
     EDFLSRLTIL DYQPKHAAHF GNIKAELSKQ GKLIGENDIH IAAHARSEGL ILVSNNLREF
     ERVIALRTEN WV
 
 
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