VAPC3_METJA
ID VAPC3_METJA Reviewed; 94 AA.
AC Q58521;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Ribonuclease VapC3;
DE Short=RNase VapC3;
DE EC=3.1.-.-;
DE AltName: Full=Putative toxin VapC3;
GN Name=vapC3; OrderedLocusNames=MJ1121;
OS Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS 10045 / NBRC 100440) (Methanococcus jannaschii).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=243232;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
RN [2]
RP POSSIBLE FUNCTION.
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=15718296; DOI=10.1093/nar/gki201;
RA Pandey D.P., Gerdes K.;
RT "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT host-associated prokaryotes.";
RL Nucleic Acids Res. 33:966-976(2005).
CC -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. An
CC RNase. Its cognate antitoxin is VapB3 (By similarity). {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305};
CC -!- SIMILARITY: Belongs to the PINc/VapC protein family. {ECO:0000305}.
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DR EMBL; L77117; AAB99123.1; -; Genomic_DNA.
DR PIR; H64439; H64439.
DR AlphaFoldDB; Q58521; -.
DR SMR; Q58521; -.
DR STRING; 243232.MJ_1121; -.
DR EnsemblBacteria; AAB99123; AAB99123; MJ_1121.
DR KEGG; mja:MJ_1121; -.
DR eggNOG; arCOG02219; Archaea.
DR HOGENOM; CLU_118482_3_5_2; -.
DR InParanoid; Q58521; -.
DR OMA; NEMIMID; -.
DR PhylomeDB; Q58521; -.
DR Proteomes; UP000000805; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:ribonuclease activity; IBA:GO_Central.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 3: Inferred from homology;
KW Hydrolase; Magnesium; Metal-binding; Nuclease; Reference proteome;
KW Toxin-antitoxin system.
FT CHAIN 1..94
FT /note="Ribonuclease VapC3"
FT /id="PRO_0000107176"
FT BINDING 6
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255"
SQ SEQUENCE 94 AA; 10719 MW; BBA60946D299EFB4 CRC64;
MDAVIDTSVI IEIFRGNKDT LYQICDYNCK ITSITVFELY CGNLKENEMI MIDSLPKLNF
DDKSSKIAGN IFKKLKKEGK IPSVKDLLIA SIFY