VAPC6_METJA
ID VAPC6_METJA Reviewed; 153 AA.
AC Q60288;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Ribonuclease VapC6 {ECO:0000255|HAMAP-Rule:MF_00265};
DE Short=RNase VapC6 {ECO:0000255|HAMAP-Rule:MF_00265};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00265};
DE AltName: Full=Putative toxin VapC6 {ECO:0000255|HAMAP-Rule:MF_00265};
GN Name=vapC6 {ECO:0000255|HAMAP-Rule:MF_00265}; OrderedLocusNames=MJECL30;
OS Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS 10045 / NBRC 100440) (Methanococcus jannaschii).
OG Plasmid large ECE.
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=243232;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
CC -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. An
CC RNase. {ECO:0000255|HAMAP-Rule:MF_00265}.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00265};
CC -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC {ECO:0000255|HAMAP-Rule:MF_00265}.
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DR EMBL; L77118; AAC37100.1; -; Genomic_DNA.
DR PIR; E64513; E64513.
DR RefSeq; WP_010890077.1; NC_001732.1.
DR AlphaFoldDB; Q60288; -.
DR SMR; Q60288; -.
DR STRING; 243232.MJ_ECL30; -.
DR EnsemblBacteria; AAC37100; AAC37100; MJ_ECL30.
DR GeneID; 1450813; -.
DR KEGG; mja:MJ_ECL30; -.
DR eggNOG; arCOG00710; Archaea.
DR HOGENOM; CLU_134210_1_1_2; -.
DR InParanoid; Q60288; -.
DR OMA; DRYAWVY; -.
DR OrthoDB; 88061at2157; -.
DR PhylomeDB; Q60288; -.
DR Proteomes; UP000000805; Plasmid large ECE.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR HAMAP; MF_00265; VapC_Nob1; 1.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR022907; VapC_family.
DR Pfam; PF01850; PIN; 1.
DR SMART; SM00670; PINc; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 3: Inferred from homology;
KW Hydrolase; Magnesium; Metal-binding; Nuclease; Plasmid; Reference proteome;
KW Toxin-antitoxin system.
FT CHAIN 1..153
FT /note="Ribonuclease VapC6"
FT /id="PRO_0000107515"
FT DOMAIN 6..152
FT /note="PINc"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00265"
FT BINDING 9
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00265"
FT BINDING 120
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00265"
SQ SEQUENCE 153 AA; 17845 MW; BDD035D67F615755 CRC64;
MSPSNVFIDS SVMVGLFIGD EKAHKLLSKL INDGFMLCIN PIVFSETMFK VTFHIALEDG
IRGVYDLKKN LNRYSWVYEE VREKIDKMIK MNYLKILDTN WEVLKLAPEI GKKYNLLTND
AIIIATCKYY RINKLATFDS DFEKVDFIEI IKE
