ID   VAPC6_MYCTO             Reviewed;         127 AA.
AC   P9WFB4; L0T639; O06783; Q7D9H2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Ribonuclease VapC6 {ECO:0000255|HAMAP-Rule:MF_00265};
DE            Short=RNase VapC6 {ECO:0000255|HAMAP-Rule:MF_00265};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00265};
DE   AltName: Full=Toxin VapC6 {ECO:0000255|HAMAP-Rule:MF_00265};
GN   Name=vapC6 {ECO:0000255|HAMAP-Rule:MF_00265}; OrderedLocusNames=MT0685;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. An
CC       RNase. The cognate antitoxin is VapB6 (By similarity).
CC       {ECO:0000255|HAMAP-Rule:MF_00265}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00265};
CC   -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_00265}.
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DR   EMBL; AE000516; AAK44910.1; -; Genomic_DNA.
DR   PIR; C70534; C70534.
DR   RefSeq; WP_003403365.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WFB4; -.
DR   SMR; P9WFB4; -.
DR   EnsemblBacteria; AAK44910; AAK44910; MT0685.
DR   GeneID; 45424616; -.
DR   KEGG; mtc:MT0685; -.
DR   PATRIC; fig|83331.31.peg.728; -.
DR   HOGENOM; CLU_118482_4_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR   HAMAP; MF_00265; VapC_Nob1; 1.
DR   InterPro; IPR022907; VapC_family.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Metal-binding; Nuclease; Toxin-antitoxin system.
FT   CHAIN           1..127
FT                   /note="Ribonuclease VapC6"
FT                   /id="PRO_0000428568"
FT   DOMAIN          26..120
FT                   /note="PINc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00265"
FT   BINDING         86
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00265"
SQ   SEQUENCE   127 AA;  13960 MW;  FE33A563A46A0975 CRC64;
     MAAATTTGTH RGLELRAAQR AVGSCEPQRA EFCRSARNAD EFDQMSRMFG DVYPDVPVPK
     SVWRWIDSAQ HRLARAGAVG ALSVVDLLIC DTAAARGLVV LHDDADYELA ERHLPDIRVR
     RVVSADD