ID   VAPC6_MYCTU             Reviewed;         127 AA.
AC   P9WFB5; L0T639; O06783; Q7D9H2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Ribonuclease VapC6 {ECO:0000255|HAMAP-Rule:MF_00265};
DE            Short=RNase VapC6 {ECO:0000255|HAMAP-Rule:MF_00265};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00265};
DE   AltName: Full=Toxin VapC6 {ECO:0000255|HAMAP-Rule:MF_00265};
GN   Name=vapC6 {ECO:0000255|HAMAP-Rule:MF_00265}; OrderedLocusNames=Rv0656c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
CC   -!- FUNCTION: Toxic component of a type II type II toxin-antitoxin (TA)
CC       system. An RNase. The cognate antitoxin is VapB6 (By similarity).
CC       {ECO:0000255|HAMAP-Rule:MF_00265}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00265};
CC   -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_00265}.
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DR   EMBL; AL123456; CCP43399.1; -; Genomic_DNA.
DR   PIR; C70534; C70534.
DR   RefSeq; NP_215170.1; NC_000962.3.
DR   RefSeq; WP_003403365.1; NZ_NVQJ01000007.1.
DR   AlphaFoldDB; P9WFB5; -.
DR   SMR; P9WFB5; -.
DR   STRING; 83332.Rv0656c; -.
DR   PaxDb; P9WFB5; -.
DR   DNASU; 888106; -.
DR   GeneID; 45424616; -.
DR   GeneID; 888106; -.
DR   KEGG; mtu:Rv0656c; -.
DR   TubercuList; Rv0656c; -.
DR   eggNOG; COG1487; Bacteria.
DR   OMA; SCYPQRA; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR   HAMAP; MF_00265; VapC_Nob1; 1.
DR   InterPro; IPR022907; VapC_family.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Metal-binding; Nuclease; Reference proteome;
KW   Toxin-antitoxin system.
FT   CHAIN           1..127
FT                   /note="Ribonuclease VapC6"
FT                   /id="PRO_0000407869"
FT   DOMAIN          26..120
FT                   /note="PINc"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00265"
FT   BINDING         86
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00265"
SQ   SEQUENCE   127 AA;  13960 MW;  FE33A563A46A0975 CRC64;
     MAAATTTGTH RGLELRAAQR AVGSCEPQRA EFCRSARNAD EFDQMSRMFG DVYPDVPVPK
     SVWRWIDSAQ HRLARAGAVG ALSVVDLLIC DTAAARGLVV LHDDADYELA ERHLPDIRVR
     RVVSADD