VAR1_VARVA
ID VAR1_VARVA Reviewed; 104 AA.
AC Q2XXR8;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 41.
DE RecName: Full=AVIToxin-VAR1 {ECO:0000312|EMBL:AAZ75583.1};
DE Flags: Precursor;
OS Varanus varius (Lace monitor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus.
OX NCBI_TaxID=8559;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Venom gland;
RX PubMed=16292255; DOI=10.1038/nature04328;
RA Fry B.G., Vidal N., Norman J.A., Vonk F.J., Scheib H., Ramjan S.F.R.,
RA Kuruppu S., Fung K., Blair Hedges S., Richardson M.K., Hodgson W.C.,
RA Ignjatovic V., Summerhayes R., Kochva E.;
RT "Early evolution of the venom system in lizards and snakes.";
RL Nature 439:584-588(2006).
CC -!- FUNCTION: Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2. Potently
CC contracts gastrointestinal (GI) smooth muscle.
CC {ECO:0000250|UniProtKB:P25687}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the AVIT (prokineticin) family. {ECO:0000305}.
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DR EMBL; DQ139877; AAZ75583.1; -; mRNA.
DR AlphaFoldDB; Q2XXR8; -.
DR SMR; Q2XXR8; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR009523; Prokineticin.
DR InterPro; IPR023569; Prokineticin_domain.
DR PANTHER; PTHR18821; PTHR18821; 1.
DR Pfam; PF06607; Prokineticin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; G-protein coupled receptor impairing toxin; Secreted;
KW Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000250"
FT CHAIN 20..104
FT /note="AVIToxin-VAR1"
FT /id="PRO_0000267482"
FT DISULFID 26..38
FT /evidence="ECO:0000250|UniProtKB:P25687"
FT DISULFID 32..50
FT /evidence="ECO:0000250|UniProtKB:P25687"
FT DISULFID 37..78
FT /evidence="ECO:0000250|UniProtKB:P25687"
FT DISULFID 60..86
FT /evidence="ECO:0000250|UniProtKB:P25687"
FT DISULFID 80..96
FT /evidence="ECO:0000250|UniProtKB:P25687"
SQ SEQUENCE 104 AA; 11217 MW; C25A96B3B59D3AA3 CRC64;
MRSLLCAPLL LLLLSAGESA VITGACDKDL QCGEGMCCAV SLWIRSIRIC TPLGSSGEDC
HPLSHKVPFD GQRKHHTCPC LPNLVCGQTS PGKYKCLPEF KNVF