ID   VAR2_VARVA              Reviewed;         104 AA.
AC   Q2XXR7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=AVIToxin-VAR2 {ECO:0000312|EMBL:AAZ75584.1};
DE   Flags: Precursor;
OS   Varanus varius (Lace monitor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus.
OX   NCBI_TaxID=8559;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=16292255; DOI=10.1038/nature04328;
RA   Fry B.G., Vidal N., Norman J.A., Vonk F.J., Scheib H., Ramjan S.F.R.,
RA   Kuruppu S., Fung K., Blair Hedges S., Richardson M.K., Hodgson W.C.,
RA   Ignjatovic V., Summerhayes R., Kochva E.;
RT   "Early evolution of the venom system in lizards and snakes.";
RL   Nature 439:584-588(2006).
CC   -!- FUNCTION: Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2. Potently
CC       contracts gastrointestinal (GI) smooth muscle.
CC       {ECO:0000250|UniProtKB:P25687}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the AVIT (prokineticin) family. {ECO:0000305}.
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DR   EMBL; DQ139878; AAZ75584.1; -; mRNA.
DR   AlphaFoldDB; Q2XXR7; -.
DR   SMR; Q2XXR7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009523; Prokineticin.
DR   InterPro; IPR023569; Prokineticin_domain.
DR   PANTHER; PTHR18821; PTHR18821; 1.
DR   Pfam; PF06607; Prokineticin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; G-protein coupled receptor impairing toxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..104
FT                   /note="AVIToxin-VAR2"
FT                   /id="PRO_0000267483"
FT   DISULFID        26..38
FT                   /evidence="ECO:0000250|UniProtKB:P25687"
FT   DISULFID        32..50
FT                   /evidence="ECO:0000250|UniProtKB:P25687"
FT   DISULFID        37..78
FT                   /evidence="ECO:0000250|UniProtKB:P25687"
FT   DISULFID        60..86
FT                   /evidence="ECO:0000250|UniProtKB:P25687"
FT   DISULFID        80..96
FT                   /evidence="ECO:0000250|UniProtKB:P25687"
SQ   SEQUENCE   104 AA;  11191 MW;  C25A83A6B59D3AA3 CRC64;
     MRSLLCAPLL LLLLSAGESA VITGACDKDL QCGEGMCCAV SLWIRSIRIC TPLGSSGEDC
     HPLSHKVPFD GQRKHHTCPC LPNLVCGQTS PGKHKCLPEF KNVF