VARB_VIOAR
ID VARB_VIOAR Reviewed; 30 AA.
AC P58447;
DT 05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT 05-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Varv peptide B;
OS Viola arvensis (European field pansy) (Field violet).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Violaceae; Viola.
OX NCBI_TaxID=97415;
RN [1]
RP PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RX PubMed=10075760; DOI=10.1021/np9803878;
RA Goeransson U., Luijendijk T., Johansson S., Bohlin L., Claeson P.;
RT "Seven novel macrocyclic polypeptides from Viola arvensis.";
RL J. Nat. Prod. 62:283-286(1999).
CC -!- FUNCTION: Probably participates in a plant defense mechanism.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin.
CC -!- PTM: This is a cyclic peptide.
CC -!- MASS SPECTROMETRY: Mass=3087; Mass_error=3; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:10075760};
CC -!- SIMILARITY: Belongs to the cyclotide family. Moebius subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00395}.
CC -!- CAUTION: This peptide is cyclic. The start position was chosen by
CC similarity to OAK1 (kalata-B1) for which the DNA sequence is known.
CC {ECO:0000305}.
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DR AlphaFoldDB; P58447; -.
DR SMR; P58447; -.
DR GO; GO:0006952; P:defense response; ISS:UniProtKB.
DR InterPro; IPR005535; Cyclotide.
DR InterPro; IPR012324; Cyclotide_moebius_CS.
DR InterPro; IPR036146; Cyclotide_sf.
DR Pfam; PF03784; Cyclotide; 1.
DR PIRSF; PIRSF037891; Cycloviolacin; 1.
DR SUPFAM; SSF57038; SSF57038; 1.
DR PROSITE; PS51052; CYCLOTIDE; 1.
DR PROSITE; PS60009; CYCLOTIDE_MOEBIUS; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Knottin; Plant defense.
FT PEPTIDE 1..30
FT /note="Varv peptide B"
FT /id="PRO_0000043623"
FT DISULFID 5..19
FT DISULFID 9..21
FT DISULFID 14..27
FT CROSSLNK 1..30
FT /note="Cyclopeptide (Gly-Asn)"
SQ SEQUENCE 30 AA; 3094 MW; 7B09691FEBAD26EE CRC64;
GLPVCGETCF GGTCNTPGCS CDPWPMCSRN